Recombinant influenza H9N2 virus with a substitution of H3 hemagglutinin transmembrane domain showed enhanced immunogenicity in mice and chicken

被引：12
作者：
Zhang, Yun [1 ]
Wei, Ying [1 ]
Liu, Kang [1 ]
Huang, Mengjiao [1 ]
Li, Ran [1 ]
Wang, Yang [1 ]
Liu, Qiliang [1 ]
Zheng, Jing [1 ]
Xue, Chunyi [1 ]
Cao, Yongchang [1 ]
机构：
[1] Sun Yat Sen Univ, Coll Life Sci, State Key Lab Biocontrol, Guangzhou 510006, Guangdong, Peoples R China
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词：
VACCINE; CHINA; PROTECTION; EVOLUTION; MUTATIONS; CYSTEINES; SITE; HA;
D O I：
10.1038/s41598-017-18054-x
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In recent years, avian influenza virus H9N2 undergoing antigenic drift represents a threat to poultry farming as well as public health. Current vaccines are restricted to inactivated vaccine strains and their related variants. In this study, a recombinant H9N2 (H9N2-TM) strain with a replaced H3 hemagglutinin (HA) transmembrane (TM) domain was generated. Virus assembly and viral protein composition were not affected by the transmembrane domain replacement. Further, the recombinant TM-replaced H9N2-TM virus could provide better inter-clade protection in both mice and chickens against H9N2, suggesting that the H3-TM-replacement could be considered as a strategy to develop efficient subtype-specific H9N2 influenza vaccines.
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页数：9
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