Iodine-Mediated Difunctionalization of Imidazopyridines with Sodium Sulfinates: Synthesis of Sulfones and Sulfides

被引：127

作者：

Guo, Yu-Jing ^{[1
]}

Lu, Shuai ^{[1
]}

Tian, Lu-Lu ^{[1
]}

Huang, En-Ling ^{[1
]}

Hao, Xin-Qi ^{[1
]}

Zhu, Xinju ^{[1
]}

Shao, Tian ^{[1
]}

Song, Mao-Ping ^{[1
]}

机构：

[1] Zhengzhou Univ, Sch Life Sci, Coll Chem & Mol Engn, 100 Sci Rd, Zhengzhou 450001, Henan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

CATALYZED REGIOSELECTIVE SULFENYLATION; C-H FUNCTIONALIZATION; S BOND FORMATION; ONE-POT; DIRECT SULFONYLATION; COUPLING REACTION; C(SP(2))-H BONDS; ROOM-TEMPERATURE; ELEMENTAL SULFUR; IMIDAZOHETEROCYCLES;

D O I：

10.1021/acs.joc.7b02734

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel iodine-induced sulfonylation and sulfenylation of imidazopyridines have been described using sodium sulfinates as the sulfur source. This strategy enables highly selective difunctionalization of imidazo[1,2-a]pyridine to access sulfones and sulfides in good yields. A wide range of substrates and functional groups were well-tolerated under optimized conditions. Moreover, control experiments have been conducted, indicating a radical pathway involved in the reaction mechanisms.

引用

页码：338 / 349

页数：12

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