Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas

被引：28

作者：

Dezso, Katalin ^{[1
]}

Halasz, Judit ^{[2
]}

Bisgaard, Hanne Cathrine ^{[3
]}

Paku, Sandor ^{[1
]}

Turanyi, Eszter ^{[1
]}

Schaff, Zsuzsa ^{[2
]}

Nagy, Peter ^{[1
]}

机构：

[1] Semmelweis Univ, Dept Pathol & Expt Canc Res 1, H-1085 Budapest, Hungary

[2] Semmelweis Univ, Dept Pathol 2, H-1085 Budapest, Hungary

[3] Univ Copenhagen, Dept Cellular & Mol Med, Danish Stem Cell Res Ctr, Copenhagen, Denmark

来源：

VIRCHOWS ARCHIV | 2008年 / 452卷 / 04期

基金：

匈牙利科学研究基金会;

关键词：

immunohistochemistry; hepatoblastoma; DLK;

D O I：

10.1007/s00428-007-0571-8

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Delta-like protein (DLK) is a membrane protein with mostly unknown function. It is expressed by several embryonic tissues among others by the hepatoblasts of rodent and human fetal livers. We have investigated in the present study if this protein is expressed in human hepatoblastomas. The presence of DLK has been studied by standard immunohistochemistry in 31 hepatoblastomas and in several differential diagnostically related tumours: hepatocellular carcinomas and in undifferentiated childhood neoplasms. All the hepatoblastomas were positive for DLK; the surrounding liver tissue remained negative. The reaction was present in the epithelial component of the tumours. The staining pattern was mostly membranous, occasionally cytoplasmic. The other studied tumours were negative for DLK, except one hepatocellular carcinoma and the differentiating cells of two ganglioneuroblastomas. Therefore, DLK seems to be a highly sensitive and specific marker for hepatoblastomas.

引用

页码：443 / 448

页数：6

共 26 条

[1] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[2] dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats [J].

Baladrón, V ;

Ruiz-Hidalgo, MJ ;

Nueda, ML ;

Díaz-Guerra, MJM ;

García-Ramírez, JJ ;

Bonvini, E ;

Gubina, E ;

Laborda, J .

EXPERIMENTAL CELL RESEARCH, 2005, 303 (02) :343-359

[3] The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system [J].

Baladrón, V ;

Ruiz-Hidalgo, MJ ;

Bonvini, E ;

Gubina, E ;

Notario, V ;

Laborda, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 291 (02) :193-204

[4]

EDMONDSON HA, 1954, CANCER-AM CANCER SOC, V7, P462, DOI 10.1002/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO

[5]

2-E

[6]

Finegold MJ, 2007, ARCH PATHOL LAB MED, V131, P520

[7] Does Fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation [J].

Floridon, C ;

Jensen, CH ;

Thorsen, P ;

Nielsen, O ;

Sunde, L ;

Westergaard, JG ;

Thomsen, SG ;

Teisner, B .

DIFFERENTIATION, 2000, 66 (01) :49-59

[8]

Hedlund GP, 2003, IN VIVO, V17, P1

[9] Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma [J].

Hsiao, CC ;

Huang, CC ;

Sheen, JM ;

Tai, MH ;

Chen, CM ;

Huang, LLH ;

Chuang, JH .

MODERN PATHOLOGY, 2005, 18 (05) :656-662

[10] Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell-mediated liver regeneration [J].

Jelnes, Peter ;

Santoni-Rugiu, Eric ;

Rasmussen, Morten ;

Friis, Susanne Lunoe ;

Nielsen, Jens Hoiriis ;

Tygstrup, Niels ;

Bisgaard, Hanne Cathrine .

HEPATOLOGY, 2007, 45 (06) :1462-1470

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