The Nuclear Molecular Imaging of Protein Brain Receptors in Chronic Pain

被引:0
作者
Su, Chen [1 ]
Hu, Rong [1 ]
Gu, Yonghong [2 ]
Han, Rui [1 ]
Yan, Xuebin [1 ]
Liao, Qin [1 ]
Huang, Dong [1 ,3 ]
机构
[1] Cent South Univ, Xiangya Hosp 3, Dept Anesthesiol, Changsha 410013, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp 3, Dept Pathol, Changsha 410013, Hunan, Peoples R China
[3] Cent South Univ, Inst Pain Med, Changsha 410013, Hunan, Peoples R China
基金
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词
Brain receptor; imaging; in vivo; pain; PET; SPECT; POSITRON-EMISSION-TOMOGRAPHY; SUBSTANCE-P; NEUROPATHIC PAIN; BASAL GANGLIA; RAT MODEL; OPIOID RECEPTORS; 5-HT2A RECEPTOR; D2; RECEPTORS; IN-VIVO; ANTERIOR CINGULATE;
D O I
10.2174/1389203717666160101124151
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chronic pain is thought to be a brain disease, but the mechanisms are not well-known. In recent years, brain imaging has become an indispensable tool for pain research. For example, nuclear molecular imaging is a safe and noninvasive technology that allows researchers to probe potential brain regions of interest with suitable biomarkers. These studies help us to understand the central mechanisms of chronic pain states in humans. Brain receptors, such as the opioid receptors, dopamine receptors, NK-1 receptors, 5-HT receptors, NMDA receptors and CGRP receptors, are effector sites of neurotransmission and have prominent roles in pain generation and modulation. With nuclear molecular imaging, density, activity and distribution of such brain receptors can be visualized in vivo. Many PET and SPECT studies have shown that there is a disturbance in the function of these receptors in chronic pain states and other neurologic and/or psychiatric pathologies. Thus, these technologies have the potential to provide us with substantial and useful information of neurochemical and neurocircuit basis for pain. In recent studies, the development of nuclear molecular imaging of these receptors in the brain is summarized.
引用
收藏
页码:559 / 569
页数:11
相关论文
共 145 条
  • [1] The brain in chronic pain: clinical implications
    Apkarian, A. Vania
    [J]. PAIN MANAGEMENT, 2011, 1 (06) : 577 - 586
  • [2] Pain and the brain: Specificity and plasticity of the brain in clinical chronic pain
    Apkarian, A. Vania
    Hashmi, Javeria A.
    Baliki, Marwan N.
    [J]. PAIN, 2011, 152 (03) : S49 - S64
  • [3] Human brain mechanisms of pain perception and regulation in health and disease
    Apkarian, AV
    Bushnell, MC
    Treede, RD
    Zubieta, JK
    [J]. EUROPEAN JOURNAL OF PAIN, 2005, 9 (04) : 463 - 484
  • [4] Effect of CGRP and sumatriptan on the BOLD response in visual cortex
    Asghar, Mohammad S.
    Hansen, Adam E.
    Larsson, Henrik B. W.
    Olesen, Jes
    Ashina, Messoud
    [J]. JOURNAL OF HEADACHE AND PAIN, 2012, 13 (02) : 159 - 166
  • [5] Evidence for a Vascular Factor in Migraine
    Asghar, Mohammad S.
    Hansen, Adam E.
    Amin, Faisal M.
    van der Geest, R. J.
    van der Koning, Patrick
    Larsson, Henrik B. W.
    Olesen, Jes
    Ashina, Messoud
    [J]. ANNALS OF NEUROLOGY, 2011, 69 (04) : 635 - 645
  • [6] Functional selectivity of opioid receptors ligands
    Audet, Nicolas
    Archer-Lahlou, Elodie
    Richard-Lalonde, Melissa
    Pineyro-Filpo, Graciela
    [J]. M S-MEDECINE SCIENCES, 2010, 26 (8-9): : 734 - 739
  • [7] Brainstem activation specific to migraine headache
    Bahra, A
    Matharu, MS
    Buchel, C
    Frackowiak, RSJ
    Goadsby, PJ
    [J]. LANCET, 2001, 357 (9261) : 1016 - 1017
  • [8] Beyond feeling: Chronic pain hurts the brain, disrupting the default-mode network dynamics
    Baliki, Marwan N.
    Geha, Paul Y.
    Apkarian, A. Vania
    Chialvo, Dante R.
    [J]. JOURNAL OF NEUROSCIENCE, 2008, 28 (06) : 1398 - 1403
  • [9] Chronic pain and the emotional brain: Specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain
    Baliki, Marwan N.
    Chialvo, Dante R.
    Geha, Paul Y.
    Levy, Robert M.
    Harden, R. Norman
    Parrish, Todd B.
    Apkarian, A. Vania
    [J]. JOURNAL OF NEUROSCIENCE, 2006, 26 (47) : 12165 - 12173
  • [10] Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic Pain
    Baliki, Marwan N.
    Geha, Paul Y.
    Fields, Howard L.
    Apkarian, A. Vania
    [J]. NEURON, 2010, 66 (01) : 149 - 160