Nanoscale drug delivery for targeted chemotherapy

被引：94

作者：

Xin, Yong ^{[1
]}

Huang, Qian ^{[2
]}

Tang, Jian-Qin ^{[3
]}

Hou, Xiao-Yang ^{[3
]}

Zhang, Pei ^{[2
]}

Zhang, Long Zhen ^{[1
]}

Jiang, Guan ^{[3
]}

机构：

[1] Affiliated Hosp Xuzhou Med Univ, Dept Radiotherapy, Xuzhou 221002, Jiangsu, Peoples R China

[2] Xuzhou Med Univ, Oncol, Xuzhou 221002, Jiangsu, Peoples R China

[3] Affiliated Hosp Xuzhou Med Univ, Dept Dermatol, Xuzhou 221002, Jiangsu, Peoples R China

来源：

CANCER LETTERS | 2016年 / 379卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Nanotechnology; Drug delivery system; Chemotherapy; Cancer therapy; LONG-CIRCULATING LIPOSOMES; BLOOD-BRAIN-BARRIER; GENE-THERAPY; CANCER-THERAPY; IN-VIVO; OPTICAL/PARAMAGNETIC NANOPROBE; MACROMOLECULAR THERAPEUTICS; TUMOR; NANOPARTICLES; RESISTANCE;

D O I：

10.1016/j.canlet.2016.05.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite significant improvements in diagnostic methods and innovations in therapies for specific cancers, effective treatments for neoplastic diseases still represent major challenges. Nanotechnology as an emerging technology has been widely used in many fields and also provides a new opportunity for the targeted delivery of cancer drugs. Nanoscale delivery of chemotherapy drugs to the tumor site is highly desirable. Recent studies have shown that nanoscale drug delivery systems not only have the ability to destroy cancer cells but may also be carriers for chemotherapy drugs. Some studies have demonstrated that delivery of chemotherapy via nanoscale carriers has greater therapeutic benefit than either treatment modality alone. In this review, novel approaches to nanoscale delivery of chemotherapy are described and recent progress in this field is discussed. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：24 / 31

页数：8

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