Zebrafish Kidney Development: Basic Science to Translational Research

被引：45
作者：
Swanhart, Lisa M. [1 ]
Cosentino, Chiara Cianciolo [1 ]
Diep, Cuong Q. [1 ]
Davidson, Alan J. [2 ]
de Caestecker, Mark [3 ]
Hukriede, Neil A. [1 ,4 ]
机构：
[1] Univ Pittsburgh, Dept Dev Biol, Pittsburgh, PA 15213 USA
[2] Univ Auckland, Dept Mol Med & Pathol, Sch Med Sci, Auckland 1, New Zealand
[3] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA
[4] Univ Pittsburgh, Drug Discovery Inst, Pittsburgh, PA 15213 USA
来源：
BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS | 2011年 / 93卷 / 02期
关键词：
kidney; zebrafish; ciliopathy; acute kidney injury; BARDET-BIEDL-SYNDROME; ACUTE-RENAL-FAILURE; LEFT-RIGHT AXIS; TUBULAR EPITHELIAL-CELLS; TRANSGENIC ZEBRAFISH; JOUBERT-SYNDROME; POSTISCHEMIC KIDNEY; HEART REGENERATION; KUPFFERS VESICLE; GENETIC SCREEN;
D O I：
10.1002/bdrc.20209
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The zebrafish has become a significant model system for studying renal organogenesis and disease, as well as for the quest for new therapeutics, because of the structural and functional simplicity of the embryonic kidney. Inroads to the nature and disease states of kidney-related ciliopathies and acute kidney injury (AKI) have been advanced by zebrafish studies. This model organism has been instrumental in the analysis of mutant gene function for human disease with respect to ciliopathies. Additionally, in the AKI field, recent work in the zebrafish has identified a bona fide adult zebrafish renal progenitor (stem) cell that is required for neo-nephrogenesis, both during the normal lifespan and in response to renal injury. Taken together, these studies solidify the zebrafish as a successful model system for studying the broad spectrum of ciliopathies and AKI that affect millions of humans worldwide, and point to a very promising future of zebrafish drug discovery. The emphasis of this review will be on the role of the zebrafish as a model for human kidney-related ciliopathies and AKI, and how our understanding of these complex pathologies is being furthered by this tiny teleost. Birth Defects Research (Part C) 93: 141-156, 2011. (C) 2011 Wiley-Liss, Inc.
引用
收藏
页码：141 / 156
页数：16
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