trans-cyclopropyl β-amino acid derivatives via asymmetric cyclopropanation using a (salen)Ru(II) catalyst

被引：47
作者：
Miller, JA
Hennessy, EJ
Marshall, WJ
Scialdone, MA
Nguyen, ST
机构：
[1] DuPont Co Inc, Cent Res & Dev, Expt Stn, Wilmington, DE 19880 USA
[2] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 20期
关键词：
D O I：
10.1021/jo0344079
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
trans-Cyclopropyl beta-amino acid derivatives can be synthesized in five steps with excellent enantioselectivities using a chiral (Salen)Ru(II) cyclopropanation catalyst in the key asymmetry-induction step. This facile synthesis proceeds with high overall yield and can be used to prepare a number of carbamate-protected (Cbz and Boc are demonstrated) beta-amino acid derivatives.
引用
收藏
页码：7884 / 7886
页数：3
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