Synthesis and evaluation of tripeptidyl α-ketoamides as human rhinovirus 3C protease inhibitors

被引：25

作者：

Chen, SH ^{[1
]}

Lamar, J

Victor, F

Snyder, N

Johnson, R

Heinz, BA

Wakulchik, M

Wang, QM

机构：

[1] Lilly Corp Ctr, Lilly Res Labs, Discovery Chem Res & Technol, Indianapolis, IN 46285 USA

[2] Lilly Corp Ctr, Lilly Res Labs, Dept Infect Dis, Indianapolis, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(03)00753-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe herein the synthesis and biological evaluation of a series of tripeptidyl alpha-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 41, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-14. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3531 / 3536

页数：6

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