Polyphenol intake and metabolic syndrome risk in European adolescents: the HELENA study

被引：31

作者：

Wisnuwardani, Ratih Wirapuspita ^{[1
,2
]}

De Henauw, Stefaan ^{[1
]}

Forsner, Maria ^{[3
,4
]}

Gottrand, Frederic ^{[5
]}

Huybrechts, Inge ^{[1
,6
]}

Knaze, Viktoria ^{[6
]}

Kersting, Mathilde ^{[7
]}

Le Donne, Cinzia ^{[8
]}

Manios, Yannis ^{[9
]}

Marcos, Ascension ^{[10
]}

Molnar, Denes ^{[11
]}

Rothwell, Joseph A. ^{[6
]}

Scalbert, Augustin ^{[6
]}

Sjostrom, Michael ^{[12
]}

Widhalm, Kurt ^{[13
]}

Moreno, Luis A. ^{[14
]}

Michels, Nathalie ^{[1
]}

机构：

[1] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth & Primary Care, C Heymanslaan 10-4K3, B-9000 Ghent, Belgium

[2] Mulawarman Univ, Fac Publ Hlth, Dept Publ Hlth Nutr, Samarinda, East Kalimantan, Indonesia

[3] Umea Univ, Dept Nursing, Umea, Sweden

[4] Dalarna Univ, Sch Educ Hlth & Social Sci, Falun, Sweden

[5] Univ Lille, Inserm, CHU Lille, U995, Lille, France

[6] Int Agcy Res Canc, WHO, 150 Cours Albert Thomas, F-69372 Lyon, France

[7] Ruhr Univ Bochum, Pediat Univ Clin Bochum, Res Dept Child Nutr, Bochum, Germany

[8] CREA Res Ctr Food & Nutr, Via Ardeatina 546, I-00178 Rome, Italy

[9] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece

[10] Inst Food Sci Technol & Nutr, Dept Metab & Nutr, Immunonutr Res Grp, Madrid, Spain

[11] Univ Pecs, Dept Pediat, Pecs, Hungary

[12] Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden

[13] Med Univ Vienna, Dept Pediat, Div Clin Nutr, Vienna, Austria

[14] Univ Zaragoza, GENUD Growth Exercise Nutr & Dev Res Grp, Fac Hlth Sci, Edificio SAI,C Pedro Cerbuna S-N, E-50009 Zaragoza, Spain

来源：

EUROPEAN JOURNAL OF NUTRITION | 2020年 / 59卷 / 02期

关键词：

Risk factor; Polyphenol; Flavonoid; Youth; Obesity; Cholesterol; TYPE-2; DIABETES-MELLITUS; BODY-MASS INDEX; CARDIOVASCULAR RISK; DIETARY POLYPHENOLS; COFFEE CONSUMPTION; ASSOCIATION; OBESITY; CHILDREN; WEIGHT; PLASMA;

D O I：

10.1007/s00394-019-01946-1

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Purpose The role of polyphenol intake during adolescence to prevent metabolic syndrome (MetS) is little explored. This study aimed to evaluate the association between intake of total polyphenols, polyphenol classes and the 10 most consumed individual polyphenols with MetS risk in European adolescents. Methods Of the cross-sectional HELENA study, 657 adolescents (54% girls; 14.8% overweight; 12.5-17.5 year) had a fasting blood sample and polyphenol intake data from two non-consecutive 24-h recalls matched with the Phenol-Explorer database. MetS was defined via the pediatric American Heart Association definition. Multilevel linear regressions examined the associations of polyphenol quartiles with MetS components, while logistic regression examined the associations with MetS risk. Results After adjusting for all potential confounders (socio-demographics and nine nutrients), total polyphenol intake, polyphenol classes and individual polyphenols were not associated with MetS risk. From all MetS components, only BMI z-score was modestly inversely associated with total polyphenol intake. Further sub analyses on polyphenol classes revealed that flavonoid intake was significantly associated with higher diastolic blood pressure and lower BMI, and phenolic acid intake was associated with higher low-density cholesterol. For individual polyphenols, the above BMI findings were often confirmed (not independent from dietary intake) and a few associations were found with insulin resistance. Conclusion Higher intakes of total polyphenols and flavonoids were inversely associated with BMI. No consistent associations were found for other MetS components.

引用

页码：801 / 812

页数：12

共 57 条

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