Herpes Infections in Suspected Cases of Yellow Fever in the Democratic Republic of the Congo

被引:2
作者
Makiala-Mandanda, Sheila [1 ,2 ]
Abbate, Jessica L. [3 ,4 ]
Pukuta-Simbu, Elisabeth [5 ]
Ahuka-Mundeke, Steve [2 ,5 ]
Muyembe-Tamfum, Jean-Jacques [2 ,5 ]
Leroy, Eric M. [3 ]
Becquart, Pierre [3 ]
机构
[1] Ctr Int Rech Med Franceville CIRMF, BP 769, Franceville, Gabon
[2] Clin Univ Kinshasa CUK, Dept Microbiol, BP 127, Kinshasa, DEM REP CONGO
[3] Univ Montpellier, CNRS, UMR IRD, Unite Mixte Rech MIVEGEC,Inst Rech Dev, F-34394 Montpellier, France
[4] Sorbonne Univ, UMI IRD, Inst Rech Dev, Unite Mixte Int UMMISCO, F-93140 Bondy, France
[5] Inst Natl Rech Biomect INRB, BP 1197, Kinshasa, DEM REP CONGO
来源
MEDICINA-LITHUANIA | 2021年 / 57卷 / 09期
关键词
herpes; yellow fever; Democratic Republic of the Congo; HUMAN CYTOMEGALOVIRUS DNA; TRANSPLANT RECIPIENTS; HEPATITIS VIRUSES; EPSTEIN-BARR; COINFECTION; PREVALENCE; DISEASE; PLASMA; BLOOD; CMV;
D O I
10.3390/medicina57090871
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In the battle to quickly identify potential yellow fever arbovirus outbreaks in the Democratic Republic of the Congo, active syndromic surveillance of acute febrile jaundice patients across the country is a powerful tool. However, patients who test negative for yellow fever virus infection are too often left without a diagnosis. By retroactively screening samples for other potential viral infections, we can both try to find sources of patient disease and gain information on how commonly they may occur and co-occur. Several human arboviruses have previously been identified, but there remain many other viral families that could be responsible for acute febrile jaundice. Here, we assessed the prevalence of human herpes viruses (HHVs) in these acute febrile jaundice disease samples. Total viral DNA was extracted from serum of 451 patients with acute febrile jaundice. We used real-time quantitative PCR to test all specimens for cytomegalovirus (CMV), herpes simplex virus (HSV), human herpes virus type 6 (HHV-6) and varicella-zoster virus (VZV). We found 21.3% had active HHV replication (13.1%, 2.4%, 6.2% and 2.4% were positive for CMV, HSV, HHV-6 and VZV, respectively), and that nearly half (45.8%) of these infections were characterized by co-infection either among HHVs or between HHVs and other viral infection, sometimes associated with acute febrile jaundice previously identified. Our results show that the role of HHV primary infection or reactivation in contributing to acute febrile jaundice disease identified through the yellow fever surveillance program should be routinely considered in diagnosing these patients.
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页数:6
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