Copper-free Sonogashira coupling reaction with PdCl2 in water under aerobic conditions

被引：279
作者：
Liang, B
Dai, MJ
Chen, JH
Yang, Z [1 ]
机构：
[1] Coll Chem, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China
[2] Peking Univ, Univ Town, Shenzhen Grad Sch, Lab Chem Genet, Shenzhen 518055, Peoples R China
[3] VivoQuest Inc, Valley Cottage, NY 10989 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 01期
关键词：
D O I：
10.1021/jo048599z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild protocol for the copper-free Sonogashira coupling of aryl iodides with terminal acetylenes in water under aerobic conditions has been developed. The use of 1 mol % PdCl2 in the presence of pyrrolidine allows the coupling reaction to proceed at room temperature or 50 degreesC with good to excellent yields.
引用
收藏
页码：391 / 393
页数：3
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