Long-term effectiveness of highly active antiretroviral therapy (HAART) in perinatally HIV-infected children in Denmark

被引:15
作者
Bracher, Linda
Valerius, Niels Henrik
Rosenfeldt, Vibeke
Herlin, Troels
Fisker, Niels
Nielsen, Henrik
Obel, Niels
机构
[1] Copenhagen Univ Hosp, Dept Paediat, Hvidovre, Denmark
[2] Skejby Univ Hosp, Dept Paediat, Aarhus, Denmark
[3] Odense Univ Hosp, Dept Paediat, Odense, Denmark
[4] Odense Univ Hosp, Dept Infect Dis, Odense, Denmark
[5] Univ Aalborg Hosp, Dept Infect Dis, Aalborg, Denmark
关键词
D O I
10.1080/00365540701203493
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The long-term impact of highly active antiretroviral therapy ( HAART) on HIV-1 infected children is not well known. The Danish Paediatric HIV Cohort Study includes all patients < 16 y of age with HIV-1 infection in Denmark. We report the complete follow-up from 1996 to 2005 of 49 perinatally infected children treated with HAART. Initial HAART included 2 nucleoside reverse-transcriptase inhibitors in combination with either a protease inhibitor ( n = 38) or a non-nucleoside reverse-transcriptase inhibitor ( n = 12). 19 ( 39%) patients were previously treated with mono-or dual therapy. Baseline characteristics were median CD4 percentage 14% and HIV-RNA viral load 4.9 log(10). Within the first 12 weeks of therapy approximately 60% achieved HIV-RNA viral load <500 copies/ml, and this remained stable for up to 8 y, although many children changed the components of HAART. The proportion of children with CD4 percentage >25% increased to 60-70% over the y of treatment. For the total cohort, 245 patient-y of observation were available with only 1 death. During our observation period there were no signs of a waning impact. The challenge remains to maintain a high adherence to therapy as the children grow into adolescence and develop more independence from family and health care staff.
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页码:799 / 804
页数:6
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