DNA origami/gold nanorod hybrid nanostructures for the circumvention of drug resistance

被引：108

作者：

Song, Linlin ^{[1
,2
,3
]}

Jiang, Qiao ^{[1
]}

Liu, Jianbing ^{[1
]}

Li, Na ^{[1
]}

Liu, Qing ^{[1
,3
]}

Dai, Luru ^{[1
]}

Gao, Yuan ^{[4
]}

Liu, Weili ^{[4
]}

Liu, Dongsheng ^{[2
]}

Ding, Baoquan ^{[1
,3
]}

机构：

[1] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Nanosyst & Hierarch Fabricat, 11 BeiYiTiao, Beijing 100190, Peoples R China

[2] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Beijing Ctr Phys & Chem Anal, Beijing 100089, Peoples R China

来源：

NANOSCALE | 2017年 / 9卷 / 23期

基金：

北京市自然科学基金;

关键词：

MULTIDRUG-RESISTANCE; BIOMEDICAL APPLICATIONS; CANCER-THERAPY; DELIVERY; NANOPARTICLES; THERAPEUTICS; TRANSPORTERS; CHEMOTHERAPY; INSIGHTS; COMPLEX;

D O I：

10.1039/c7nr02222k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We herein demonstrate that DNA origami can work as a multifunctional platform integrating a chemotherapeutic drug (doxorubicin), gold nanorods and a tumour-specific aptamer MUC-1, to realize the effective circumvention of drug resistance. Doxorubicin (DOX) was loaded efficiently onto DNA origami through base pair intercalation and surface-modified gold nanorods (AuNRs) were assembled onto the DNA origami through DNA hybridization. Due to the active targeting effect of the assembled aptamers, the multifunctional nanostructures achieved increased cellular internalization of DOX and AuNRs. Upon near-infrared (NIR) laser irradiation, the P-glycoprotein (multidrug resistance pump) expression of multidrug resistant MCF-7 (MCF-7/ADR) cells was down-regulated, achieving the synergistically chemotherapeutic (DOX) and photothermal (AuNRs) effects.

引用

页码：7750 / 7754

页数：5

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