Intra-abdominal Rhizopus microsporus Infection Successfully Treated by Combined Aggressive Surgical, Antifungal, and Iron Chelating Therapy

被引：11

作者：

Ting, Joseph Yuk ^{[1
]}

Chan, Shu-yan ^{[1
]}

Lung, David Christopher ^{[2
]}

Chi-chung, Alvin ^{[1
]}

Chiang, Alan Kwok-shing ^{[1
]}

Ha, Shau-yin ^{[1
]}

Tsoi, Nelson Nai-shun ^{[1
]}

Chan, Godfrey Chi-Fung ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Paediat & Adolescent Med, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China

[2] Tuen Mun Hosp, Dept Clin Pathol, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2010年 / 32卷 / 06期

关键词：

zygomycosis; Rhizopus; iron chelator; WOODEN TONGUE DEPRESSORS; SALVAGE THERAPY; MUCORMYCOSIS; ZYGOMYCOSIS; POSACONAZOLE; DEFERASIROX; DEFEROXAMINE; DEFERIPRONE; OUTBREAK; PATIENT;

D O I：

10.1097/MPH.0b013e3181e622bf

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Zygomycetes are widely distributed in the environment as inhabitants of soil and decaying matter. On rare occasions, these organisms can cause invasive infections in immunocompromised hosts. As zygomycetes are resistant to most conventional antifungal agents, its infection is often fatal. We report 2 cases of unusual intra-abdominal Rhizopus microsporus infection in children with acute leukemia as a result of an unprecedented outbreak due to oral intake of contaminated allopurinol tablets and ready-to-eat food items. Among the 2 patients, one of them survived after aggressive combined surgical, antifungal (AmBisome, Caspofungin, and Posaconazole) and iron chelation therapy.

引用

页码：E238 / E240

页数：3

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