Chemoenzymatic synthesis of glycosylphosphatidylinositol-anchored glycopeptides

被引：26

作者：

Wu, Zhimeng ^{[1
]}

Guo, Xueqing ^{[1
]}

Guo, Zhongwu ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 31期

关键词：

CHEMICAL-SYNTHESIS; SORTASE-A; PROTEIN; LIGATION; PEPTIDE; BIOSYNTHESIS;

D O I：

10.1039/c0cc00828a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

MUC1 glycopeptide was efficiently coupled to glycosylphosphatidylinositol (GPI) derivatives by sortase A (SrtA), verifying that SrtA can accept sterically hindered glycopeptide as substrate for ligation with GPIs. This work has established a practical method for the chemoenzymatic synthesis of GPI-linked glycopeptides.

引用

收藏

页码：5773 / 5774

页数：2

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