microRNA-1274a, a modulator of sorafenib induced a disintegrin and metalloproteinase 9 (ADAM9) down-regulation in hepatocellular carcinoma

被引：52

作者：

Zhou, Changchun ^{[2
,3
]}

Liu, Jibing ^{[4
]}

Li, Yang ^{[5
]}

Liu, Li ^{[1
,2
]}

Zhang, Xiaojiao ^{[1
,2
]}

Ma, Cheng-Yuan ^{[6
]}

Hua, Shu-Cheng ^{[5
]}

Yang, Ming ^{[1
,2
]}

Yuan, Qipeng ^{[1
,2
]}

机构：

[1] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China

[2] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing, Peoples R China

[3] Shandong Canc Hosp, Clin Lab, Jinan, Shandong, Peoples R China

[4] Shandong Canc Hosp, Dept Intervent Surg, Jinan, Shandong, Peoples R China

[5] Jilin Univ, Hosp 1, Dept Respirat, Changchun 130023, Jilin Province, Peoples R China

[6] Jilin Univ, Hosp 1, Dept Neurosurg, Changchun 130023, Jilin Province, Peoples R China

来源：

FEBS LETTERS | 2011年 / 585卷 / 12期

关键词：

microRNA-1274a; Sorafenib; Hepatocellular cancer; ADAM9; INDUCED APOPTOSIS; BREAST-CANCER; EXPRESSION; CELLS;

D O I：

10.1016/j.febslet.2011.04.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with poor prognosis. Sorafenib, a multikinase inhibitor, has been widely used to treat patients with advanced HCC in clinic. We postulated that microRNAs (miRNA) might be involved in HCC target-chemotherapy with sorafenib. MiRNA profile of HepG2 was evaluated after cells were treated with vehicle or sorafenib and alterations in miRNA expression occurred with 14 miRNAs. MiR-1274a, which is up-regulated by sorafenib, could significantly repress expression of ADAM9, a protease that is involved in sorafenib target-therapy of HCC, in HCC cells. Taken together, our data emphasizes a new miRNA-based mechanism of sorafenib antitumor therapy. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1828 / 1834

页数：7

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