microRNA-1274a, a modulator of sorafenib induced a disintegrin and metalloproteinase 9 (ADAM9) down-regulation in hepatocellular carcinoma

被引：52
作者：
Zhou, Changchun [2 ,3 ]
Liu, Jibing [4 ]
Li, Yang [5 ]
Liu, Li [1 ,2 ]
Zhang, Xiaojiao [1 ,2 ]
Ma, Cheng-Yuan [6 ]
Hua, Shu-Cheng [5 ]
Yang, Ming [1 ,2 ]
Yuan, Qipeng [1 ,2 ]
机构：
[1] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China
[2] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing, Peoples R China
[3] Shandong Canc Hosp, Clin Lab, Jinan, Shandong, Peoples R China
[4] Shandong Canc Hosp, Dept Intervent Surg, Jinan, Shandong, Peoples R China
[5] Jilin Univ, Hosp 1, Dept Respirat, Changchun 130023, Jilin Province, Peoples R China
[6] Jilin Univ, Hosp 1, Dept Neurosurg, Changchun 130023, Jilin Province, Peoples R China
来源：
FEBS LETTERS | 2011年 / 585卷 / 12期
关键词：
microRNA-1274a; Sorafenib; Hepatocellular cancer; ADAM9; INDUCED APOPTOSIS; BREAST-CANCER; EXPRESSION; CELLS;
D O I：
10.1016/j.febslet.2011.04.040
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with poor prognosis. Sorafenib, a multikinase inhibitor, has been widely used to treat patients with advanced HCC in clinic. We postulated that microRNAs (miRNA) might be involved in HCC target-chemotherapy with sorafenib. MiRNA profile of HepG2 was evaluated after cells were treated with vehicle or sorafenib and alterations in miRNA expression occurred with 14 miRNAs. MiR-1274a, which is up-regulated by sorafenib, could significantly repress expression of ADAM9, a protease that is involved in sorafenib target-therapy of HCC, in HCC cells. Taken together, our data emphasizes a new miRNA-based mechanism of sorafenib antitumor therapy. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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收藏
页码：1828 / 1834
页数：7
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