RETRACTED: MicroRNA-520g induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7 (vol 589, pg 102, 2015) (Retracted article. See vol. 596, pg. 526, 2022)

被引：38

作者：

Kan, Heping ^{[1
]}

Guo, Wenbin ^{[2
]}

Huang, Yuqi ^{[1
]}

Liu, Dingli ^{[3
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Hepatobiliary Surg, Guangzhou 510515, Guangdong, Peoples R China

[2] Southern Med Univ, Affiliated Hosp 3, Dept Urol, Guangzhou 510000, Guangdong, Peoples R China

[3] Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou 510515, Guangdong, Peoples R China

来源：

FEBS LETTERS | 2015年 / 589卷 / 01期

关键词：

MicroRNA-520g; Hepatocellular carcinoma; Epithelial-mesenchymal transition; SMAD family member 7; Cancer metastasis; TGF-BETA; IDENTIFICATION; CONTRIBUTES; ANTAGONIST; SIGNATURES; INVASION; RECEPTOR; CANCER; MIRNAS;

D O I：

10.1016/j.febslet.2014.11.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Aberrant expression of miRNAs contributes to HCC development. Here, we observed elevated miR-520g expression in tumor samples from HCC patients with relapse and metastasis, and this high miR-520g expression was correlated with poor survival. Through gain-and loss-of-function studies, miR-520g was demonstrated to facilitate HCC cell migration, invasion and epithelial-mesenchymal transition (EMT). SMAD7 was identified as a direct target of miR-520g. Accordingly, we conclude that high miR-520g expression promotes HCC cell mobility and EMT by targeting SMAD7, and this is correlated with reduced survival in HCC patients. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：102 / 109

页数：8

共 25 条

[1] MicroRNA signatures in human cancers [J].