Vanillic acid derivatives from the green algae Cladophora socialis as potent protein tyrosine phosphatase 1B inhibitors

被引：51

作者：

Feng, Yunjiang ^{[1
]}

Carroll, Anthony R. ^{[1
]}

Addepalli, Rama ^{[1
]}

Fechner, Gregory A. ^{[1
]}

Avery, Vicky M. ^{[1
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst Cell & Mol Therapies, Nat Prod Dis, Nathan, Qld 4111, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 11期

关键词：

D O I：

10.1021/np070225o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A novel vanillic acid derivative (1) and its sulfate adduct (2) were isolated from a green algae, Cladophora socialis. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments. Both compounds showed potent inhibitory activity against protein tyrosine phosphatase 113 (PTP1B), an enzyme involved in the regulation of insulin cell signaling. Compounds I and 2 had IC50 values of 3.7 and 1.7 mu M, respectively.

引用

页码：1790 / 1792

页数：3

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