Expression of Mitochondrial Uncoupling Protein UCP2 in the Brain of Rats after Hippocampal Injury Inflicted by Kainic Acid

被引：6
|
作者：
Lebedev, D. S. [1 ]
Arkhipov, V. I. [1 ,2 ]
机构：
[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142292, Russia
[2] Pushchino State Univ, Pushchino, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 150卷 / 02期
关键词：
hippocampus; kainic acid; gene expression; mitochondrial uncoupling proteins;
D O I：
10.1007/s10517-010-1100-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The expression of mitochondrial protein UCP2 and cytochrome C-oxidase subunit III genes in the hippocampus and prefrontal cortex was evaluated by real-time PCR 3 and 7 days after microinjection of kainic acid into the dorsal hippocampus. In contrast to cytochrome C-oxidase subunit III mRNA, the level of UCP2 mRNA in the hippocampus increased 1 week after microinjection of kainic acid. The expression of both genes in the prefrontal cortex did not differ from the control. Presumably, activation of UCP2 synthesis in hippocampal injury indicates the neuroprotective effects of this protein.
引用
收藏
页码：185 / 187
页数：3
相关论文
共 50 条
  • [1] Expression of Mitochondrial Uncoupling Protein UCP2 in the Brain of Rats after Hippocampal Injury Inflicted by Kainic Acid
    D. S. Lebedev
    V. I. Arkhipov
    Bulletin of Experimental Biology and Medicine, 2010, 150 : 185 - 187
  • [2] Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury
    Bechmann, I
    Diano, S
    Warden, CH
    Bartfai, T
    Nitsch, R
    Horvath, TL
    BIOCHEMICAL PHARMACOLOGY, 2002, 64 (03) : 363 - 367
  • [3] Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary
    Diano, S
    Urbanski, HF
    Horvath, B
    Bechmann, I
    Kagiya, A
    Nemeth, G
    Naftolin, F
    Warden, CH
    Horvath, TL
    ENDOCRINOLOGY, 2000, 141 (11) : 4226 - 4238
  • [4] Recruitment of mitochondrial uncoupling protein UCP2 after lipopolysaccharide induction
    Ruzicka, M
    Skobisová, E
    Dlasková, A
    Santorova, J
    Smolková, K
    Spacek, T
    Zácková, M
    Modriansky, M
    Jezek, P
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (04): : 809 - 821
  • [5] Hydroperoxide fatty acid cycling via mitochondrial uncoupling protein UCP2
    Jaburek, M
    Miyamoto, S
    Di Mascio, P
    Garlid, KD
    Jezek, P
    BIOPHYSICAL JOURNAL, 2004, 86 (01) : 613A - 613A
  • [6] Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2
    Jaburek, M
    Miyamoto, S
    Di Mascio, P
    Garlid, KD
    Jezek, P
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (51) : 53097 - 53102
  • [7] Mitochondrial uncoupling protein (UCP2) gene expression is regulated by miR-2909
    Kaul, Deepak
    Sharma, S.
    Garg, A.
    BLOOD CELLS MOLECULES AND DISEASES, 2015, 55 (01) : 89 - 93
  • [8] Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism
    Diano, Sabrina
    Horvath, Tamas L.
    TRENDS IN MOLECULAR MEDICINE, 2012, 18 (01) : 52 - 58
  • [9] Expression and role of mitochondrial Uncoupling Protein 2 (UCP2) during early Xenopus embryogenesis
    Toya, Masanori
    Hashimoto, Chikara
    ZOOLOGICAL SCIENCE, 2004, 21 (12) : 1297 - 1297
  • [10] Uncoupling protein UCP2: When mitochondrial activity meets immunity
    Emre, Yalin
    Nuebel, Tobias
    FEBS LETTERS, 2010, 584 (08) : 1437 - 1442
12345