Chimonanthus nitens Oliv. essential oil mitigates lipopolysaccharide-induced acute lung injury in rats

被引：18
|
作者：
Wan, Min [1 ]
Yao, Yu-fei [2 ]
Wu, Wei [1 ]
Fu, Wang-wei [1 ]
Wu, Rui-ting [1 ]
Li, Wen-juan [1 ]
机构：
[1] Nanchang Univ, State Key Lab Food Sci & Technol, 235 Nanjing East Rd, Nanchang 330047, Jiangxi, Peoples R China
[2] Jiangxi Univ Tradit Chinese Med, Affiliated Hosp, Nanchang 330006, Jiangxi, Peoples R China
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2021年 / 156卷
基金：
中国国家自然科学基金;
关键词：
Chimonanthus nitens Oliv; essential oil; Acute lung injury; Inflammation; Antioxidant defense; Short-chain fatty acids; INFLAMMATORY RESPONSE; LEAVES; IL-10; MICE;
D O I：
10.1016/j.fct.2021.112445
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
This study aimed to evaluate the effect of Chimonanthus nitens Oliv. essential oil (named CEO) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats. In the present study, 21 compounds were characterized in CEO by gas chromatography-mass spectrometry analysis. Furthermore, animal data suggested that CEO could protect rats against ALI, as evidence by increasing white blood cell count, reducing immune organ index and improving lung histopathological changes in rats subjected to LPS. Reduction of the levels of IL-1 beta was also shown during CEO-triggering lung protection in rats. Meanwhile, these protective effects of CEO were accompanied by the attenuation of lipid oxidation, and elevation of antioxidant enzymes, suggesting that enhancement of antioxidant defense was linked to its lung protection. Moreover, a combination with CEO and LPS significantly elevated short-chain fatty acids (SCFAs) compared with LPS alone via increasing propionic, i-butyric, butyric and i-valeric acid on LPS-induced ALI in rats. Therefore, our findings indicated that CEO could alleviate LPS-caused ALI in rats by controlling aberrant inflammation, correcting the redox system, and modulating SCFAs in rats.
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页数：8
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