Multichannel wearable fNIRS-EEG system for long-term clinical monitoring

被引:59
作者
Kassab, Ali [1 ]
Le Lan, Jerome [2 ]
Tremblay, Julie [3 ]
Vannasing, Phetsamone [3 ]
Dehbozorgi, Mahya [2 ]
Pouliot, Philippe [2 ,5 ]
Gallagher, Anne [3 ]
Lesage, Frederic [2 ]
Sawan, Mohamad [2 ]
Dang Khoa Nguyen [1 ,4 ]
机构
[1] Univ Montreal, Res Ctr, Ctr Hosp Univ Montreal, Montreal, PQ H2X 0A9, Canada
[2] Ecole Polytech Montreal, Dept Elect Engn, Montreal, PQ H3T 1J4, Canada
[3] Univ Montreal, Res Ctr, Hop St Justine, Montreal, PQ H3T 1C4, Canada
[4] Ctr Hosp Univ Montreal, Dept Neurol, Hop Notre Dame, Montreal, PQ H2L 4M1, Canada
[5] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada
基金
加拿大健康研究院;
关键词
portable near-infrared spectroscopy; electroencephalography; cerebral hemodynamics; functional brain imaging and monitoring; limb-shaking transient ischemic attacks; epilepsy; NEAR-INFRARED SPECTROSCOPY; VISUAL-EVOKED-POTENTIALS; ANEURYSMAL SUBARACHNOID HEMORRHAGE; CEREBRAL BLOOD OXYGENATION; FUNCTIONAL MRI; HUMAN-BRAIN; OPTICAL PATHLENGTH; LANGUAGE DOMINANCE; INVOS; 3100; NIRS;
D O I
10.1002/hbm.23849
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Continuous brain imaging techniques can be beneficial for the monitoring of neurological pathologies (such as epilepsy or stroke) and neuroimaging protocols involving movement. Among existing ones, functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG) have the advantage of being noninvasive, nonobstructive, inexpensive, yield portable solutions, and offer complementary monitoring of electrical and local hemodynamic activities. This article presents a novel system with 128 fNIRS channels and 32 EEG channels with the potential to cover a larger fraction of the adult superficial cortex than earlier works, is integrated with 32 EEG channels, is light and battery-powered to improve portability, and can transmit data wirelessly to an interface for real-time display of electrical and hemodynamic activities. A novel fNIRS-EEG stretchable cap, two analog channels for auxiliary data (e.g., electrocardiogram), eight digital triggers for event-related protocols and an internal accelerometer for movement artifacts removal contribute to improve data acquisition quality. The system can run continuously for 24h. Following instrumentation validation and reliability on a solid phantom, performance was evaluated on (1) 12 healthy participants during either a visual (checkerboard) task at rest or while pedalling on a stationary bicycle or a cognitive (language) task and (2) 4 patients admitted either to the epilepsy (n=3) or stroke (n=1) units. Data analysis confirmed expected hemodynamic variations during validation recordings and useful clinical information during in-hospital testing. To the best of our knowledge, this is the first demonstration of a wearable wireless multichannel fNIRS-EEG monitoring system in patients with neurological conditions. Hum Brain Mapp 39:7-23, 2018. (c) 2017 Wiley Periodicals, Inc.
引用
收藏
页码:7 / 23
页数:17
相关论文
共 102 条
[31]   A comparison of the monitors INVOS3100 and NIRO500 in detecting changes in cerebral oxygenation [J].
Grubhofer, G ;
Tonninger, W ;
Keznicki, P ;
Skyllouriotis, P ;
Ehrlich, M ;
Hiesmayr, M ;
Lassnigg, A .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1999, 43 (04) :470-475
[32]   Spatial sensitivity and penetration depth of three cerebral oxygenation monitors [J].
Gunadi, Sonny ;
Leung, Terence S. ;
Elwell, Clare E. ;
Tachtsidis, Ilias .
BIOMEDICAL OPTICS EXPRESS, 2014, 5 (09) :2896-2912
[33]   Cerebral oxygenation after birth - a comparison of INVOS® and FORE-SIGHT™ near-infrared spectroscopy oximeters [J].
Hessel, Trine W. ;
Hyttel-Sorensen, Simon ;
Greisen, Gorm .
ACTA PAEDIATRICA, 2014, 103 (05) :488-493
[34]   Simultaneous recording of task-induced changes in blood oxygenation, volume, and flow using diffuse optical imaging and arterial spin-labeling MRI [J].
Hoge, RD ;
Franceschini, MA ;
Covolan, RJM ;
Huppert, T ;
Mandeville, JB ;
Boas, DA .
NEUROIMAGE, 2005, 25 (03) :701-707
[35]   HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain [J].
Huppert, Theodore J. ;
Diamond, Solomon G. ;
Franceschini, Maria A. ;
Boas, David A. .
APPLIED OPTICS, 2009, 48 (10) :D280-D298
[36]   A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans [J].
Huppert, TJ ;
Hoge, RD ;
Diamond, SG ;
Franceschini, MA ;
Boas, DA .
NEUROIMAGE, 2006, 29 (02) :368-382
[37]   Effect of mechanical optical clearing on near-infrared spectroscopy [J].
Idelson, Christopher R. ;
Vogt, William C. ;
King-Casas, Brooks ;
LaConte, Stephen M. ;
Rylander, Christopher G. .
LASERS IN SURGERY AND MEDICINE, 2015, 47 (06) :495-502
[38]  
Jing-Guo Zhao, 2009, Health, V1, P47, DOI 10.4236/health.2009.11009
[39]  
JOBSIS FF, 1977, J APPL PHYSIOL, V43, P858
[40]   Cortical effects of user training in a motor imagery based brain-computer interface measured by fNIRS and EEG [J].
Kaiser, Vera ;
Bauernfeind, Guenther ;
Kreilinger, Alex ;
Kaufmann, Tobias ;
Kuebler, Andrea ;
Neuper, Christa ;
Mueller-Putz, Gernot R. .
NEUROIMAGE, 2014, 85 :432-444