The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease

被引：125
|
作者：
Kessler, Thorsten [1 ]
Vilne, Baiba [1 ]
Schunkert, Heribert [1 ,2 ]
机构：
[1] Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany
[2] DZHK German Ctr Cardiovasc Res eV, Partner Site Munich Heart Alliance, Munich, Germany
来源：
EMBO MOLECULAR MEDICINE | 2016年 / 8卷 / 07期
关键词：
atherosclerosis; coronary artery disease; genome-wide association studies; myocardial infarction; CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; SOLUBLE GUANYLATE-CYCLASE; SUBTILISIN/KEXIN TYPE 9; SUSCEPTIBILITY LOCUS; LDL CHOLESTEROL; HEART-DISEASE; MYOCARDIAL-INFARCTION; REDUCING LIPIDS; BLOOD-PRESSURE;
D O I：
10.15252/emmm.201506174
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly with traditional risk factors precipitates their manifestation. Whereas the implications of a positive family history for individual risk have been known for a long time, only in the past few years have genome-wide association studies (GWAS) shed light on the underlying genetic variations. Here, we review these studies designed to increase our understanding of the pathophysiology of cardiovascular diseases, particularly coronary artery disease and myocardial infarction. We focus on the newly established pathways to exemplify the translation from the identification of risk-related genetic variants to new preventive and therapeutic strategies for cardiovascular disease.
引用
收藏
页码：688 / 701
页数：14
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