Hematogones Predict Better Outcome in Allogeneic Hematopoietic Stem Cell Transplantation Irrespective of Graft Sources

被引:11
作者
Ishio, Takashi [1 ]
Sugita, Junichi [1 ]
Tateno, Takahiro [1 ]
Hidaka, Daisuke [1 ]
Hayase, Eiko [1 ]
Shiratori, Souichi [1 ]
Okada, Kohei [1 ]
Goto, Hideki [1 ]
Onozawa, Masahiro [1 ]
Nakagawa, Masao [1 ]
Hashimoto, Daigo [1 ]
Kahata, Kaoru [1 ]
Fujimoto, Katsuya [1 ]
Endo, Tomoyuki [1 ]
Kondo, Takeshi [1 ]
Teshima, Takanori [1 ]
机构
[1] Hokkaido Univ, Fac Med, Dept Hematol, Sapporo, Hokkaido, Japan
基金
日本学术振兴会;
关键词
Hematogones; Bone marrow transplantation; Peripheral blood stem cell transplantation; Cord blood transplantation; GVHD-free relapse-free survival; CORD BLOOD TRANSPLANTATION; VERSUS-HOST-DISEASE; ACUTE MYELOID-LEUKEMIA; BONE-MARROW; B-CELL; RESIDUAL DISEASE; IMPACT; ENGRAFTMENT; PRECURSORS; SURVIVAL;
D O I
10.1016/j.bbmt.2018.06.011
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Benign precursors of B lymphocytes, termed hematogones, are observed in the regenerative state of hematopoiesis following chemotherapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous studies have demonstrated that expansion of hematogones correlates with better clinical outcomes after allo-HSCT. We retrospectively analyzed the association between hematogones and clinical outcomes in 309 consecutive patients who underwent allo-HSCT, which is the largest population-based cohort reported so far. The incidence of hematogones was significantly higher in complete remission (CR) patients at the time of transplantation than in non-CR patients, after myeloablative conditioning than after reduced-intensity conditioning, with tacrolimus-based graftversus-host disease (GVHD) prophylaxis than with cyclosporine-based prophylaxis, and with disease other than malignant lymphoma (all P < .05). Patients with hematogones developed less acute GVHD and infections than did those without them (P < .05). Emergence of hematogones was associated with superior GVHD-free relapse-free survival and lower nonrelapse mortality, and was an independent prognostic factor for overall survival, irrespective of donor sources. (C) 2018 American Society for Blood and Marrow Transplantation.
引用
收藏
页码:1990 / 1996
页数:7
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