Copper-promoted C1-H amination of pyrrolo[1,2-a]quinoxaline with N-fluorobenzenesulfonimide

被引：9

作者：

Hao, Di ^{[1
]}

Yang, Zhen ^{[1
]}

Liu, Yali ^{[1
]}

Li, Yang ^{[1
]}

Liu, Yan ^{[1
]}

Liu, Ping ^{[1
]}

机构：

[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi City 832004, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2022年 / 1267卷

基金：

中国国家自然科学基金;

关键词：

Pyrrolo[1; 2-a ]quinoxaline; N – fluorobenzenesulfonimide; C-Hamination; VITRO ANTIMALARIAL ACTIVITY; IN-VITRO; BIOLOGICAL EVALUATION; DERIVATIVES; INHIBITORS; FLUORINATION; IMIDATION;

D O I：

10.1016/j.molstruc.2022.133636

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A copper-promoted direct C1-amination of pyrrolo[1,2-a]quinoxalines with N-fluorobenzenesulfonimide (NFSI) has been achieved. A series of C1-aminated pyrrolo[1,2-a]quinoxalines were obtained with broad substrate scope and good functional group tolerance. Gram-scale synthesis and further derivation of this aminated product were also investigated. Mechanism studies suggest that this reaction probably under-goes a free-radical process.(c) 2022 Elsevier B.V. All rights reserved.

引用

页数：6

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