Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV

被引：19
作者：
Castillo-Mancilla, Jose R. [1 ]
Morrow, Mary [2 ]
Coyle, Ryan P. [1 ]
Coleman, Stacey S. [3 ]
Zheng, Jia-Hua [4 ,5 ]
Ellison, Lucas [4 ,5 ]
Bushman, Lane R. [4 ,5 ]
Kiser, Jennifer J. [4 ,5 ]
Anderson, Peter L. [4 ,5 ]
MaWhinney, Samantha [2 ]
机构：
[1] Univ Colorado AMC, Sch Med, Div Infect Dis, Aurora, CO USA
[2] Colorado Sch Publ Hlth, Dept Biostat & Bioinformat, Aurora, CO USA
[3] Univ Colorado Hosp, Aurora, CO USA
[4] Univ Colorado AMC, Skaggs Sch Pharm & Pharmaceut Sci, Colorado Antiviral Pharmacol Lab, Aurora, CO USA
[5] Univ Colorado AMC, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Aurora, CO USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 09期
基金：
美国国家卫生研究院;
关键词：
low-level viremia; adherence; dried blood spots; tenofovir diphosphate; antiretroviral therapy; TENOFOVIR-DIPHOSPHATE; EMTRICITABINE; BLIPS;
D O I：
10.1093/ofid/ofab463
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The drivers of low-level viremia (LLV) between 20 and 200 copies/mL remain unclear. In 1042 person-visits from 497 persons with HIV on tenofovir disoproxil fumarate-containing antiretroviral therapy (ART), the association between LLV and cumulative antiretroviral adherence (quantified using tenofovir diphosphate [TFV-DP] in dried blood spots) was assessed. Lower TFV-DP levels were associated with higher odds of LLV. As TFV-DP (fmol/punch) categories decreased from >1650 to 800-1650; 800-1650 to <800; and >1650 to <800, the adjusted odds ratios for LLV vs HIV VL <20 copies/mL were 2.0 (95% CI, 1.2-3.1), 2.4 (95% CI, 1.1-5.0), and 4.6 (95% CI, 2.2-9.9), respectively. This suggests that adherence could impact LLV.
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页数：5
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