Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV

被引：22

作者：

Castillo-Mancilla, Jose R. ^{[1
]}

Morrow, Mary ^{[2
]}

Coyle, Ryan P. ^{[1
]}

Coleman, Stacey S. ^{[3
]}

Zheng, Jia-Hua ^{[4
,5
]}

Ellison, Lucas ^{[4
,5
]}

Bushman, Lane R. ^{[4
,5
]}

Kiser, Jennifer J. ^{[4
,5
]}

Anderson, Peter L. ^{[4
,5
]}

MaWhinney, Samantha ^{[2
]}

机构：

[1] Univ Colorado AMC, Sch Med, Div Infect Dis, Aurora, CO USA

[2] Colorado Sch Publ Hlth, Dept Biostat & Bioinformat, Aurora, CO USA

[3] Univ Colorado Hosp, Aurora, CO USA

[4] Univ Colorado AMC, Skaggs Sch Pharm & Pharmaceut Sci, Colorado Antiviral Pharmacol Lab, Aurora, CO USA

[5] Univ Colorado AMC, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Aurora, CO USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 09期

基金：

美国国家卫生研究院;

关键词：

low-level viremia; adherence; dried blood spots; tenofovir diphosphate; antiretroviral therapy; TENOFOVIR-DIPHOSPHATE; EMTRICITABINE; BLIPS;

D O I：

10.1093/ofid/ofab463

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The drivers of low-level viremia (LLV) between 20 and 200 copies/mL remain unclear. In 1042 person-visits from 497 persons with HIV on tenofovir disoproxil fumarate-containing antiretroviral therapy (ART), the association between LLV and cumulative antiretroviral adherence (quantified using tenofovir diphosphate [TFV-DP] in dried blood spots) was assessed. Lower TFV-DP levels were associated with higher odds of LLV. As TFV-DP (fmol/punch) categories decreased from >1650 to 800-1650; 800-1650 to <800; and >1650 to <800, the adjusted odds ratios for LLV vs HIV VL <20 copies/mL were 2.0 (95% CI, 1.2-3.1), 2.4 (95% CI, 1.1-5.0), and 4.6 (95% CI, 2.2-9.9), respectively. This suggests that adherence could impact LLV.

引用

页数：5

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