Nanovectorization of DNA Through Cells Using Protamine Complexation

被引：5

作者：

Boukari, Khaoula ^{[1
]}

Caoduro, Cecile ^{[1
]}

Kacem, Raoudha ^{[1
]}

Skandrani, Nadia ^{[1
]}

Borg, Christophe ^{[3
]}

Boulahdour, Hatem ^{[1
]}

Gharbi, Tijani ^{[1
]}

Delage-Mourroux, Regis ^{[2
]}

Hervouet, Eric ^{[2
]}

Pudlo, Marc ^{[4
]}

Picaud, Fabien ^{[1
]}

机构：

[1] Univ Bourgogne Franche Comte, CHU UFR SMP, UFR Sci & Tech, Nanomed Imagery & Therapeut Lab,EA 4662, 19 Rue Ambroise Pare, F-25030 Besancon, France

[2] Univ Franche Comte, Express Genique & Pathol Syst Nerveux Cent, Lab Biochim, EA3922,SFRIBCT FED 4234,UFR Sci & Tech, Besancon, France

[3] Univ Bourgogne Franche Comte IFR133, EFS Bourgogne Franche Comte, Inserm 1098, Besancon, France

[4] Univ Bourgogne Franche Comte, EA Fonct & Dysfonct Epitheliales 4267, UFR Sci Med & Pharmaceut, 19 Rue Ambroise Pare, F-25030 Besancon, France

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2016年 / 249卷 / 04期

关键词：

Nanovectorization; Protamine; Simulation; WALLED CARBON NANOTUBES; DRUG-DELIVERY VEHICLES; IN-VITRO; TRANSLOCATION; THERAPEUTICS; FUNCTIONALIZATION; ORGANIZATION; DOXORUBICIN; CHALLENGES; MEMBRANES;

D O I：

10.1007/s00232-016-9890-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine-DNA-CNT complex.

引用

页码：493 / 501

页数：9

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