Oxygen delivering biomaterials for tissue engineering

被引：154

作者：

Farris, Ashley L. ^{[1
,2
]}

Rindone, Alexandra N. ^{[1
,2
]}

Grayson, Warren L. ^{[1
,2
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Translat TE Ctr, 400 N Broadway,Smith 5023, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA

[4] Johns Hopkins Univ, Inst NanoBioTechnol, Baltimore, MD 21218 USA

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 20期

关键词：

HYPERBARIC-OXYGEN; BONE-FORMATION; CELL-SURVIVAL; PERFLUOROCARBON EMULSIONS; BLOOD SUBSTITUTES; STEM-CELLS; IN-VITRO; HYPOXIA; CARRIERS; HYDROGEL;

D O I：

10.1039/c5tb02635k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Tissue engineering (TE) has provided promising strategies for regenerating tissue defects, but few TE approaches have been translated for clinical applications. One major barrier in TE is providing adequate oxygen supply to implanted tissue scaffolds, since oxygen diffusion from surrounding vasculature in vivo is limited to the periphery of the scaffolds. Moreover, oxygen is also an important signaling molecule for controlling stem cell differentiation within TE scaffolds. Various technologies have been developed to increase oxygen delivery in vivo and enhance the effectiveness of TE strategies. Such technologies include hyperbaric oxygen therapy, perfluorocarbon- and hemoglobin-based oxygen carriers, and oxygen-generating, peroxide-based materials. Here, we provide an overview of the underlying mechanisms and how these technologies have been utilized for in vivo TE applications. Emerging technologies and future prospects for oxygen delivery in TE are also discussed to evaluate the progress of this field towards clinical translation.

引用

页码：3422 / 3432

页数：11

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