The role of glutamine in intensive care unit patients:: Mechanisms of action and clinical outcome

被引：25

作者：

Coëffier, M ^{[1
]}

Déchelotte, P ^{[1
]}

机构：

[1] Fac Med Pharm, ADEN EA 3234, IFR 23, F-76183 Rouen, France

来源：

NUTRITION REVIEWS | 2005年 / 63卷 / 02期

关键词：

glutamine; nutritional support; critical care; nosocomial infections; insulin resistance;

D O I：

10.1301/nr.2005.feb.65-69

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Patients in the intensive care unit are at high risk of glutamine depletion and subsequent complications. Several controlled studies and a metaanalysis have concluded that glutamine supplementation has beneficial effects on the clinical outcome of critically ill and surgical patients. These results may be explained by glutamine's influences on the inflammatory response, oxidative stress, cell protection, and the gut barrier. In addition, glutamine may also improve glucose metabolism by reducing insulin resistance.

引用

页码：65 / 69

页数：5

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