THE DRUG DEADLOCK

被引：66

作者：

Abbott, Alison

机构：

来源：

NATURE | 2010年 / 468卷 / 7321期

关键词：

SCHIZOPHRENIA;

D O I：

10.1038/468158a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The biology is too complicated. Pharma companies are quitting. Where are schizophrenia drugs going to come from?

引用

页码：158 / 159

页数：2

共 4 条

[1] A summary of the FDA-NIMH-MATRICS Workshop on Clinical Trial Design for Neurocognitive Drugs for Schizophrenia. [J].

Buchanan, RW ;

Davis, M ;

Goff, D ;

Green, MF ;

Keefe, RSE ;

Leon, AC ;

Nuechterlein, KH ;

Laughren, T ;

Levin, R ;

Stover, E ;

Fenton, W ;

Marder, SR .

SCHIZOPHRENIA BULLETIN, 2005, 31 (01) :5-19

[2] The NIMH-MATRICS consensus statement on negative symptoms [J].

Kirkpatrick, B ;

Fenton, WS ;

Carpenter, WT ;

Marder, SR .

SCHIZOPHRENIA BULLETIN, 2006, 32 (02) :214-219

[3] Effectiveness of antipsychotic drugs in patients with chronic schizophrenia [J].

Lieberman, JA ;

Stroup, TS ;

McEvoy, JP ;

Swartz, MS ;

Rosenheck, RA ;

Perkins, DO ;

Keefe, RSE ;

Davis, SM ;

Davis, CE ;

Lebowitz, BD ;

Severe, J ;

Hsiao, JK .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (12) :1209-1223

[4] Large recurrent microdeletions associated with schizophrenia [J].

Stefansson, Hreinn ;

Rujescu, Dan ;

Cichon, Sven ;

Pietilainen, Olli P. H. ;

Ingason, Andres ;

Steinberg, Stacy ;

Fossdal, Ragnheidur ;

Sigurdsson, Engilbert ;

Sigmundsson, Thordur ;

Buizer-Voskamp, Jacobine E. ;

Hansen, Thomas ;

Jakobsen, Klaus D. ;

Muglia, Pierandrea ;

Francks, Clyde ;

Matthews, Paul M. ;

Gylfason, Arnaldur ;

Halldorsson, Bjarni V. ;

Gudbjartsson, Daniel ;

Thorgeirsson, Thorgeir E. ;

Sigurdsson, Asgeir ;

Jonasdottir, Adalbjorg ;

Jonasdottir, Aslaug ;

Bjornsson, Asgeir ;

Mattiasdottir, Sigurborg ;

Blondal, Thorarinn ;

Haraldsson, Magnus ;

Magnusdottir, Brynja B. ;

Giegling, Ina ;

Moeller, Hans-Juergen ;

Hartmann, Annette ;

Shianna, Kevin V. ;

Ge, Dongliang ;

Need, Anna C. ;

Crombie, Caroline ;

Fraser, Gillian ;

Walker, Nicholas ;

Lonnqvist, Jouko ;

Suvisaari, Jaana ;

Tuulio-Henriksson, Annamarie ;

Paunio, Tiina ;

Toulopoulou, Timi ;

Bramon, Elvira ;

Di Forti, Marta ;

Murray, Robin ;

Ruggeri, Mirella ;

Vassos, Evangelos ;

Tosato, Sarah ;

Walshe, Muriel ;

Li, Tao ;

Vasilescu, Catalina .

NATURE, 2008, 455 (7210) :232-U61

← 1 →