First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells

被引：36
作者：
Hojjat-Farsangi, M. [1 ,2 ]
Daneshmanesh, A. H. [1 ,2 ]
Khan, A. S. [1 ,2 ]
Shetye, J. [1 ,2 ]
Mozaffari, F. [1 ,2 ]
Kharaziha, P. [1 ,2 ]
Rathje, L-S [1 ,2 ,3 ]
Kokhaei, P. [1 ,2 ,4 ,5 ]
Hansson, L. [1 ,2 ,6 ]
Vagberg, J. [3 ]
Bystrom, S. [3 ]
Olsson, E. [3 ]
Lofberg, C. [3 ]
Norstrom, C. [3 ]
Schultz, J. [3 ]
Norin, M. [3 ]
Olin, T. [3 ]
Osterborg, A. [1 ,2 ,6 ]
Mellstedt, H. [1 ,2 ]
Moshfegh, A. [1 ,2 ,3 ]
机构：
[1] Karolinska Univ Hosp Solna, CCK, Dept Oncol Pathol, Immune & Gene Therapy Lab, Stockholm, Sweden
[2] Karolinska Inst, Stockholm, Sweden
[3] Kancera AB, Solna, Sweden
[4] Semnan Univ Med Sci, Canc Res Ctr, Semnan, Iran
[5] Semnan Univ Med Sci, Dept Immunol, Semnan, Iran
[6] Karolinska Univ Hosp Solna, Dept Hematol, Stockholm, Sweden
来源：
LEUKEMIA | 2018年 / 32卷 / 10期
基金：
瑞典研究理事会;
关键词：
D O I：
10.1038/s41375-018-0113-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
[No abstract available]
引用
收藏
页码：2291 / 2295
页数：5
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