Intracellular pH-Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics

被引：295

作者：

Lee, Chia-Hung ^{[2
]}

Cheng, Shih-Hsun ^{[1
,5
]}

Huang, I-Ping ^{[1
]}

Souris, Jeffrey S. ^{[4
]}

Yang, Chung-Shi ^{[2
]}

Mou, Chung-Yuan ^{[3
]}

Lo, Leu-Wei ^{[1
]}

机构：

[1] Natl Hlth Res Inst, Div Med Engn Res, Zhunan Miaoli 350, Taiwan

[2] Natl Hlth Res Inst, Ctr Nanomed Res, Zhunan 350, Miaoli, Taiwan

[3] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[4] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA

[5] Natl Tsing Hua Univ, Inst NanoEngn & MicroSyst, Hsinchu 300, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 44期

关键词：

antitumor agents; apoptosis; controlled release; doxorubicin; mesoporous silica; CONTROLLED DRUG-RELEASE; DIFFERENT MORPHOLOGIES; DELIVERY-SYSTEM; DOXORUBICIN; MOLECULES; FUNCTIONALIZATION; PEPTIDE; DNA;

D O I：

10.1002/anie.201002639

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8214 / 8219

页数：6

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