Intracellular pH-Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics

被引：297

作者：

Lee, Chia-Hung ^{[2
]}

Cheng, Shih-Hsun ^{[1
,5
]}

Huang, I-Ping ^{[1
]}

Souris, Jeffrey S. ^{[4
]}

Yang, Chung-Shi ^{[2
]}

Mou, Chung-Yuan ^{[3
]}

Lo, Leu-Wei ^{[1
]}

机构：

[1] Natl Hlth Res Inst, Div Med Engn Res, Zhunan Miaoli 350, Taiwan

[2] Natl Hlth Res Inst, Ctr Nanomed Res, Zhunan 350, Miaoli, Taiwan

[3] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[4] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA

[5] Natl Tsing Hua Univ, Inst NanoEngn & MicroSyst, Hsinchu 300, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 44期

关键词：

antitumor agents; apoptosis; controlled release; doxorubicin; mesoporous silica; CONTROLLED DRUG-RELEASE; DIFFERENT MORPHOLOGIES; DELIVERY-SYSTEM; DOXORUBICIN; MOLECULES; FUNCTIONALIZATION; PEPTIDE; DNA;

D O I：

10.1002/anie.201002639

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8214 / 8219

页数：6

共 58 条

[1] Near-Infrared Emitting Fluorophore-Doped Calcium Phosphate Nanoparticles for In Vivo Imaging of Human Breast Cancer [J].

Altinoglu, Erhan i. ;

Russin, Timothy J. ;

Kaiser, James M. ;

Barth, Brian M. ;

Eklund, Peter C. ;

Kester, Mark ;

Adair, James H. .

ACS NANO, 2008, 2 (10) :2075-2084

[2]

Angelos S., 2008, ANGEW CHEM, V120, P2254

[3] pH-responsive supramolecular nanovalves based on cucurbit[6]uril pseudorotaxanes [J].

Angelos, Sarah ;

Yang, Ying-Wei ;

Patel, Kaushik ;

Stoddart, J. Fraser ;

Zink, Jeffrey I. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (12) :2222-2226

[4] pH Clock-Operated Mechanized Nanoparticles [J].

Angelos, Sarah ;

Khashab, Niveen M. ;

Yang, Ying-Wei ;

Trabolsi, Ali ;

Khatib, Hussam A. ;

Stoddart, J. Fraser ;

Zink, Jeffrey I. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (36) :12912-+

[5] Systematic delivery of chloroquine and promethazine using pH-sensitive polymers [J].

Attama, AA ;

Ezeamama, UF .

DRUG DELIVERY, 2005, 12 (02) :103-107

[6] In vivo antitumor activity of the folate-conjugated pH-Sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments [J].

Bae, Younsoo ;

Nishiyama, Nobuhiro ;

Kataoka, Kazunori .

BIOCONJUGATE CHEMISTRY, 2007, 18 (04) :1131-1139

[7]

Bernardos A., 2009, ANGEW CHEM, V121, P5998

[8] Enzyme-Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose [J].

Bernardos, Andrea ;

Aznar, Elena ;

Dolores Marcos, Maria ;

Martinez-Manez, Ramon ;

Sancenon, Felix ;

Soto, Juan ;

Manuel Barat, Jose ;

Amoros, Pedro .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (32) :5884-5887

[9] Controlled release of vitamin B2 using mesoporous materials functionalized with amine-bearing gate-like scaffoldings [J].

Bernardos, Andrea ;

Aznar, Elena ;

Coll, Carmen ;

Martinez-Manez, Ramon ;

Manuel Barat, Jose ;

Dolores Marcos, Ma. ;

Sancenon, Felix ;

Benito, Angel ;

Soto, Juan .

JOURNAL OF CONTROLLED RELEASE, 2008, 131 (03) :181-189

[10]

BODLEY A, 1989, CANCER RES, V49, P5969

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