Intracellular pH-Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics

被引：295
作者：
Lee, Chia-Hung [2 ]
Cheng, Shih-Hsun [1 ,5 ]
Huang, I-Ping [1 ]
Souris, Jeffrey S. [4 ]
Yang, Chung-Shi [2 ]
Mou, Chung-Yuan [3 ]
Lo, Leu-Wei [1 ]
机构：
[1] Natl Hlth Res Inst, Div Med Engn Res, Zhunan Miaoli 350, Taiwan
[2] Natl Hlth Res Inst, Ctr Nanomed Res, Zhunan 350, Miaoli, Taiwan
[3] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
[4] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA
[5] Natl Tsing Hua Univ, Inst NanoEngn & MicroSyst, Hsinchu 300, Taiwan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 44期
关键词：
antitumor agents; apoptosis; controlled release; doxorubicin; mesoporous silica; CONTROLLED DRUG-RELEASE; DIFFERENT MORPHOLOGIES; DELIVERY-SYSTEM; DOXORUBICIN; MOLECULES; FUNCTIONALIZATION; PEPTIDE; DNA;
D O I：
10.1002/anie.201002639
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：8214 / 8219
页数：6
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