EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma

被引：18

作者：

Chen, Hsuan-Yu ^{[1
,2
,3
]}

Liu, Chia-Hsin ^{[1
,4
,5
]}

Chang, Ya-Hsuan ^{[1
]}

Yu, Sung-Liang ^{[6
]}

Ho, Bing-Ching ^{[6
]}

Hsu, Chung-Ping ^{[7
]}

Yang, Tsung-Ying ^{[7
]}

Chen, Kun-Chieh ^{[7
]}

Hsu, Kuo-Hsuan ^{[7
]}

Tseng, Jeng-Sen ^{[7
]}

Hsia, Jiun-Yi ^{[7
]}

Chuang, Cheng-Yen ^{[7
]}

Chang, Chi-Sheng ^{[6
]}

Li, Yu-Cheng ^{[1
]}

Li, Ker-Chau ^{[1
]}

Chang, Gee-Chen ^{[7
,8
,9
]}

Yang, Pan-Chyr ^{[6
,10
,11
]}

机构：

[1] Acad Sinica, Inst Stat Sci, Taipei 11529, Taiwan

[2] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan

[3] Natl Taiwan Univ, Coll Life Sci, Taipei 10764, Taiwan

[4] Acad Sinica, Taiwan Int Grad Program, Bioinformat Program, Taipei 115, Taiwan

[5] Natl Yang Ming Univ, Inst Biomed Informat, Taipei 112, Taiwan

[6] Natl Taiwan Univ, Ctr Genom Med, Taipei 10764, Taiwan

[7] Taichung Vet Gen Hosp, Taichung, Taiwan

[8] Natl Yang Ming Univ, Sch Med, Fac Med, Taipei 112, Taiwan

[9] Taichung Vet Gen Hosp, Ctr Comprehens Canc, Taichung, Taiwan

[10] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan

[11] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

来源：

ONCOTARGET | 2016年 / 7卷 / 08期

关键词：

lung adenocarcinoma; DNA copy number abundance; ErbB family; EGFR-activating mutation; prognosis; GROWTH-FACTOR RECEPTOR; NEVER SMOKERS; CANCER; EXPRESSION; THERAPY; TARGETS;

D O I：

10.18632/oncotarget.7029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, EGFR-activating mutation status and DNA copy number abundances of members of ErbB family were measured in 261 lung adenocarcinomas. The associations between DNA copy number abundances of ErbB family, EGFR-activating mutation status, and prognosis were explored. Results showed that DNA copy number abundances of EGFR, ERBB2, ERBB3, and ERBB4 had associations with overall survival in lung adenocarcinoma with EGFR-activating mutations. In the stratification analysis, only ERBB2 showed significant discrepancy in patients carrying wild type EGFR and other members of ErbB family in patients carrying EGFR-activating mutation. This indicated that CNAs of ErbB family had effect modifications of EGFR-activating mutation status. Findings of this study demonstrate potential molecular guidance of patient management of lung adenocarcinoma with or without EGFR-activating mutations.

引用

页码：9017 / 9025

页数：9

共 33 条

[31] Untangling the ErbB signalling network [J].