Metal Complexes as Antiviral Agents for SARS-CoV-2

被引：76

作者：

Karges, Johannes ^{[1
]}

Cohen, Seth M. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr, La Jolla, CA 92093 USA

来源：

CHEMBIOCHEM | 2021年 / 22卷 / 16期

关键词：

antiviral agents; bioinorganic chemistry; coronavirus; COVID-19; metallodrugs; CORONAVIRUS; AURANOFIN; SARS; METALLODRUGS; PROTEINS; EBSELEN; DRUG;

D O I：

10.1002/cbic.202100186

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The severe acute respiratory syndrome - coronavirus 2 (SARS-CoV-2), the infectious agent responsible for COVID-19 - has caused more than 2.5 million deaths worldwide and triggered a global pandemic. Even with successful vaccines being delivered, there is an urgent need for novel treatments to combat SARS-CoV-2, and other emerging viral diseases. While several organic small molecule drug candidates are in development, some effort has also been devoted towards the application of metal complexes as potential antiviral agents against SARS-CoV-2. Herein, the metal complexes that have been reported to show antiviral activity against SARS-CoV-2 or one of its target proteins are described and their proposed mechanisms of action are discussed.

引用

页码：2600 / 2607

页数：8

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