Diastereoselective synthesis of γ-lactams by a one-pot, four-component reaction

被引：58
作者：
Wei, Jingqiang
Shaw, Jared T.
机构：
[1] Broad Inst Harvard, Cambridge, MA 02142 USA
[2] MIT, Cambridge, MA 02142 USA
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 20期
关键词：
D O I：
10.1021/ol701911u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetraand pentasubstituted gamma-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.
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收藏
页码：4077 / 4080
页数：4
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