Prognostic impact of cytological fluid tumor markers in non-small cell lung cancer

被引：5

作者：

Cho, Arthur ^{[1
]}

Hur, Jin ^{[2
,3
,5
]}

Hong, Yoo Jin ^{[2
,3
]}

Lee, Hye-Jeong ^{[2
,3
]}

Kim, Young Jin ^{[2
,3
]}

Hong, Sae Rom ^{[2
,3
]}

Suh, Young Joo ^{[2
,3
]}

Im, Dong Jin ^{[2
,3
]}

Kim, Yun Jung ^{[2
,3
]}

Lee, Jae Seok ^{[4
]}

Shim, Hyo Sup ^{[4
]}

Choi, Byoung Wook ^{[2
,3
]}

机构：

[1] Yonsei Univ, Coll Med, Severance Hosp, Dept Nucl Med, Seoul 120749, South Korea

[2] Yonsei Univ, Coll Med, Severance Hosp, Dept Radiol, Seoul 120749, South Korea

[3] Yonsei Univ, Coll Med, Severance Hosp, Res Inst Radiol Sci, Seoul 120749, South Korea

[4] Yonsei Univ, Coll Med, Severance Hosp, Dept Pathol, Seoul 120749, South Korea

[5] Yonsei Univ, Coll Med, Severance Hosp, Dept Radiol, 50 Yonsei Ro, Seoul 120752, South Korea

来源：

TUMOR BIOLOGY | 2016年 / 37卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Serum CYFRA 21-1; Cytologic tumor marker; Cytologic SCC Ag; Prognosis; NSCLC; NEEDLE ASPIRATION BIOPSY; OPACITY PULMONARY-LESIONS; CARCINOEMBRYONIC ANTIGEN; CARCINOMA ANTIGEN; CYFRA; 21-1; CEA; NSCLC; DIAGNOSIS; PREDICTS; FRAGMENT;

D O I：

10.1007/s13277-015-4034-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The serum tumor markers CYFRA 21-1, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) are useful in diagnosis and prognosis of non-small cell lung cancer (NSCLC). Cytologic tumor markers obtained during needle aspiration biopsies (NAB) of lung lesions are useful for NSCLC diagnosis. This study investigated the incremental prognostic value of cytologic tumor markers compared to serum tumor markers. This prospective study included 253 patients diagnosed with NSCLC by NAB with cytologic tumor marker analysis. Levels of cytologic CYFRA 21-1, CEA, SCCA, and their serum counterparts were followed up for survival analysis. Optimal cutoff values for each tumor marker were obtained for overall survival (OS) and progression-free survival (PFS) analyses. All patients were followed up for a median of 22.8 months. Using cutoff values of 0.44 ng/ml for C-SCCA, 2.0 ng/ml for S-SCCA, and 3.3 ng/ml for S-CYFRA, a multivariate analysis revealed that high S-SCCA (hazard ratio, HR, 1.84) and high C-SCCA (HR, 1.63) were independent predictive factors of OS. The 3-year overall survival rate was 55 vs. 80 % for high and low C-SCCA, respectively. Cytologic tumor marker level detection is easily obtainable and provides prognostic information for NSCLC. Cytologic tumor markers provide comparable prognostic information relative to serum tumor markers, with C-SCCA acting as a strong prognostic factor of overall survival and PFS.

引用

页码：3205 / 3213

页数：9

共 25 条

[1] Decline in serum carcinoembryonic antigen and cytokeratin 19 fragment during chemotherapy predicts objective response and survival in patients with advanced nonsmall cell lung cancer [J].