Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

被引：40

作者：

Elfaki, Imadeldin ^{[1
]}

Mir, Rashid ^{[2
]}

Mir, Mohammad Muzaffar ^{[3
]}

AbuDuhier, Faisel M. ^{[2
]}

Babakr, Abdullatif Taha ^{[4
]}

Barnawi, Jameel ^{[2
]}

机构：

[1] Univ Tabuk, Dept Biochem, Fac Sci, Tabuk 71491, Saudi Arabia

[2] Univ Tabuk, Fac Appl Med Sci, Dept Med Lab Technol, Prince Fahd Bin Sultan Res Chair, Tabuk 71491, Saudi Arabia

[3] Univ Bisha, Dept Basic Med Sci, Coll Med, Bisha 61992, Saudi Arabia

[4] Umm Al Qura Univ, Dept Med Biochem, Fac Med, Mecca 57039, Saudi Arabia

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2019年 / 9卷 / 04期

关键词：

diabetes mellitus; cardiovascular disease; atherosclerosis; MicroRNA; single nucleotide polymorphisms (snps); SINGLE-NUCLEOTIDE POLYMORPHISMS; CORONARY-ARTERY-DISEASE; NF-KAPPA-B; MYOCARDIAL-INFARCTION; POSTTRANSCRIPTIONAL REGULATION; EXPRESSION CONTRIBUTE; GLUCOSE-HOMEOSTASIS; NEGATIVE REGULATOR; INSULIN-RESISTANCE; BLOOD-PRESSURE;

D O I：

10.3390/jpm9040051

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

MicroRNAs (miRNAs) are endogenous, small (18-23 nucleotides), non-coding RNA molecules. They regulate the posttranscriptional expression of their target genes. MiRNAs control vital physiological processes such as metabolism, development, differentiation, cell cycle and apoptosis. The control of the gene expression by miRNAs requires efficient binding between the miRNA and their target mRNAs. Genome-wide association studies (GWASs) have suggested the association of single-nucleotide polymorphisms (SNPs) with certain diseases in various populations. Gene polymorphisms of miRNA target sites have been implicated in diseases such as cancers, diabetes, cardiovascular and Parkinson's disease. Likewise, gene polymorphisms of miRNAs have been reported to be associated with diseases. In this review, we discuss the SNPs in miRNA genes that have been associated with diabetes and atherosclerotic cardiovascular disease in different populations. We also discuss briefly the potential underlining mechanisms through which these SNPs increase the risk of developing these diseases.

引用

页数：18

共 147 条

[1] MIR146A rs2910164 (G/C) Polymorphism is Associated with Incidence of Preeclampsia in Gestational Diabetes Patients [J].

Abo-Elmatty, Dina M. ;

Mehanna, Eman T. .

BIOCHEMICAL GENETICS, 2019, 57 (02) :222-233

[2]

Almutairi F.M., 2019, Indian J. Public Health Res. Dev, V10, P600, DOI [10.5958/0976-5506.2019.00118.9, DOI 10.5958/0976-5506.2019.00118.9]

[3] Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus [J].

Assmann, Tais S. ;

Duarte, Guilherme C. K. ;

Brondani, Leticia A. ;

de Freitas, Pedro H. O. ;

Martins, Egina M. ;

Canani, Luis H. ;

Crispim, Daisy .

ACTA DIABETOLOGICA, 2017, 54 (05) :433-441

[4] A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing [J].

Babiarz, Joshua E. ;

Hsu, Ruby ;

Melton, Collin ;

Thomas, Molly ;

Ullian, Erik M. ;

Blelloch, Robert .

RNA, 2011, 17 (08) :1489-1501

[5] Function of microRNA-375 and microRNA-124a in pancreas and brain [J].

Baroukh, Nadine N. ;

Van Obberghen, Emmanuel .

FEBS JOURNAL, 2009, 276 (22) :6509-6521

[6] MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population [J].

Bastami, Milad ;

Ghaderian, Sayyed Mohamad Hossein ;

Omrani, Mir Davood ;

Mirfakhraie, Reza ;

Vakili, Hossein ;

Parsa, Saeed Alipour ;

Nariman-Saleh-Fam, Ziba ;

Masotti, Andrea .

GENETIC TESTING AND MOLECULAR BIOMARKERS, 2016, 20 (05) :241-248

[7] MicroRNAs: The Role in Autoimmune Inflammation [J].

Baulina, N. M. ;

Kulakova, O. G. ;

Favorova, O. O. .

ACTA NATURAE, 2016, 8 (01) :21-33

[8] Polymorphism in microRNA-196a2 contributes to the risk of cardiovascular disease in type 2 diabetes patients [J].

Buraczynska, Monika ;

Zukowski, Pawel ;

Wacinski, Piotr ;

Ksiazek, Katarzyna ;

Zaluska, Wojciech .

JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2014, 28 (05) :617-620

[9] Chapter 11: Genome-Wide Association Studies [J].

Bush, William S. ;

Moore, Jason H. .

PLOS COMPUTATIONAL BIOLOGY, 2012, 8 (12)

[10] The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population [J].

Cai, Meng-yun ;

Cheng, Jie ;

Zhou, Meng-yuan ;

Liang, Li-li ;

Lian, Si-min ;

Xie, Xiao-shan ;

Xu, Shun ;

Liu, Xinguang ;

Xiong, Xing-dong .

LIPIDS IN HEALTH AND DISEASE, 2018, 17

← 1 2 3 4 5 6 7 8 9 10 →