Tobacco smoke and bladder cancer: the current research status and the future challenges

被引：0
作者：
Wu, Ye [1 ]
Shu, Jinping [1 ]
Yuan, Yuan [1 ]
Zhou, Dian [1 ]
机构：
[1] Anhui Med Univ, Affiliated Hosp 1, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2019年 / 12卷 / 11期
关键词：
Bladder cancer; tobacco smoke; research progress; mechanisms; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN UROTHELIAL CELLS; DNA-DAMAGE; KAPPA-B; ACTIVATION; PATHWAY; PROLIFERATION; RISK; CESSATION; CURCUMIN;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Bladder cancer is the ninth most common malignant tumors worldwide. Tobacco smoke is the primary risk factor for bladder cancer. The relationship and underlying mechanisms between tobacco smoke and the disease etiology are not, however, fully delineated. Understanding the role of tobacco smoke in the initiation and progression of bladder cancer is essential for clarifying the molecular mechanisms, improving future strategies for prevention, early detection, exploring novel diagnostic markers and effective therapeutics. Therefore, this review summarizes the relationship between tobacco smoke and bladder cancer. The direction of future research and the challenges on tobacco smoke-associated bladder cancer are also outlined.
引用
收藏
页码：12633 / 12639
页数：7
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