Palladium-Catalyzed Regio- and Stereoselective Hydrosilylation of Electron-Deficient Alkynes

被引：68

作者：

Sumida, Yuto ^{[1
]}

Kato, Tomoe ^{[1
]}

Yoshida, Suguru ^{[1
]}

Hosoya, Takamitsu ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Biol Chem Lab, Grad Sch Biomed Sci, Inst Biomat & Bioengn,Chiyoda Ku, Tokyo 1010062, Japan

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 06期

关键词：

HYDROSTANNATION; EFFICIENT; (Z)-ALKENYLSILANES; HYDROSILATION; COMPLEXES; SILICON; OLEFINS; KETONES;

D O I：

10.1021/ol300279c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly regio- and stereoselective hydrosilylation applicable to a broad range of electron-deficient alkynes has been established using palladium catalysis. The synthetic utility of the method has been demonstrated by further transformations of alpha-silylalkenes, particularly Hiyama coupling and stereoinverting iododesilylation followed by Suzuki-Miyaura coupling, which enables stereodivergent syntheses of alpha-arylenoates.

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收藏

页码：1552 / 1555

页数：4

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