Fiber optic microendoscopy for preclinical study of bacterial infection dynamics

被引：13

作者：

Mufti, Nooman ^{[1
]}

Kong, Ying ^{[2
]}

Cirillo, Jeffrey D. ^{[2
]}

Maitland, Kristen C. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Biomed Engn, Zachry Engn Ctr 337, College Stn, TX 77843 USA

[2] Texas A&M Hlth Sci Ctr, Dept Microbial & Mol Pathogenesis, College Stn, TX 77843 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2011年 / 2卷 / 05期

关键词：

CONFOCAL REFLECTANCE MICROSCOPE; IN-VIVO; FLUORESCENCE; TUBERCULOSIS; TISSUES; SYSTEM; LENS;

D O I：

10.1364/BOE.2.001121

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 mu m resolution, a 750 mu m field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Guerin (BCG) bacteria were detected in situ from inocula down to 104 and 107 colony forming units, respectively. (C) 2011 Optical Society of America

引用

页码：1121 / 1134

页数：14

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