Identification of host cell proteins which interact with herpes simplex virus type 1 tegument protein pUL37

被引：11
|
作者：
Kelly, Barbara J. [1 ,2 ]
Diefenbach, Eve [1 ,2 ]
Fraefel, Cornel [3 ]
Diefenbach, Russell J. [1 ,2 ]
机构：
[1] Univ Sydney, Ctr Virus Res, Westmead Millennium Inst, Westmead, NSW 2145, Australia
[2] Westmead Hosp, Westmead, NSW 2145, Australia
[3] Univ Zurich, Inst Virol, CH-8057 Zurich, Switzerland
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 417卷 / 03期
基金：
英国医学研究理事会;
关键词：
pUL37; Herpes simplex virus; Herpesvirus; Host-pathogen interactions; Tegument; EARLY GENE-EXPRESSION; B KINASE COMPLEX; HUMAN CYTOMEGALOVIRUS; FAMILIAL DYSAUTONOMIA; UL37; PROTEIN; IKAP; ENVELOPMENT; PHENOTYPES; MUTATIONS; HOMOLOG;
D O I：
10.1016/j.bbrc.2011.12.044
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The herpes simplex virus type 1 (HSV-1) structural tegument protein pUL37, which is conserved across the Helpesviridae family, is known to be essential for secondary envelopment during the egress of viral particles. To shed light on additional roles of pUL37 during viral replication a yeast two-hybrid screen of a human brain cDNA library was undertaken. This screen identified ten host cell proteins as potential pUL37 interactors. One of the interactors, serine threonine kinase TAOK3, was subsequently confirmed to interact with pUL37 using an in vitro pulldown assay. Such host cell/pUL37 interactions provide further insights into the multifunctional role of this herpesviral tegument protein. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：961 / 965
页数：5
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