Thiosubstrates of cholinesterases of different origin

被引：3
|
作者：
Rozengart, E. V. [1 ]
Basova, N. E. [1 ]
机构：
[1] Russian Acad Sci, IM Sechenov Evolutionary Physiol & Biochem Inst, St Petersburg 196140, Russia
来源：
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY | 2008年 / 44卷 / 01期
关键词：
comparative enzymology; cholinesterase; substrate specificity; thiosubstrates;
D O I：
10.1134/S0022093008010027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Review of the own and literature data on investigation of substrate specificity of different cholinesterases using thiosubstrates is presented. Dependence of cholinesteratic hydrolysis parameters on various elements of their structure-the acyl part, alkyl "bridge" between ester atom and onium group, and the molecule ammonium grouping-is considered using 44 thioesters in total. A comparative enzymological analysis of the substrate specificity is performed with use of thiocholine esters of acetic, propionic, and butyric acids for 40 cholinesterase preparations of mammals, insects, mollusks, and plants.
引用
收藏
页码：12 / 23
页数：12
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