Assessment of antigenic difference of equine influenza virus strains by challenge study in horses

被引：10

作者：

Yamanakaa, Takashi ^{[1
]}

Nemotoa, Manabu ^{[1
,2
]}

Bannaia, Hiroshi ^{[1
]}

Tsujimuraa, Koji ^{[1
]}

Kondoa, Takashi ^{[1
]}

Matsumuraa, Tomio ^{[1
]}

Gildeab, Sarah ^{[2
]}

Cullinaneb, Ann ^{[2
]}

机构：

[1] Japan Racing Assoc, Equine Res Inst, Shimotsuke, Tochigi, Japan

[2] Irish Equine Ctr, Virol Unit, Naas, Kildare, Ireland

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2016年 / 10卷 / 06期

关键词：

challenge study; equine influenza; H3N8; inactivated whole vaccine; VACCINES; SURVEILLANCE; RACEHORSES; EFFICACY; JAPAN;

D O I：

10.1111/irv.12418

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We previously reported that horse antiserum against the Japanese equine influenza vaccine virus, A/equine/La Plata/1993 (LP93) exhibited reduced cross-neutralization against some Florida sublineage Clade (Fc) 2 viruses, for example, A/equine/Carlow/2011 (CL11). As a result, Japanese vaccine manufacturers will replace LP93 with A/equine/Yokohama/aq13/2010 (Y10, Fc2). To assess the benefit of updating the vaccine, five horses vaccinated with inactivated Y10 vaccine and five vaccinated with inactivated LP93 were challenged by exposure to a nebulized aerosol of CL11. The durations of pyrexia (>= 38.5 degrees C) and other adverse clinical symptoms experienced by the Y10 group were significantly shorter than those of the LP93 group.

引用

页码：536 / 539

页数：4

共 34 条

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