Assessment of antigenic difference of equine influenza virus strains by challenge study in horses

被引：10
|
作者：
Yamanakaa, Takashi [1 ]
Nemotoa, Manabu [1 ,2 ]
Bannaia, Hiroshi [1 ]
Tsujimuraa, Koji [1 ]
Kondoa, Takashi [1 ]
Matsumuraa, Tomio [1 ]
Gildeab, Sarah [2 ]
Cullinaneb, Ann [2 ]
机构：
[1] Japan Racing Assoc, Equine Res Inst, Shimotsuke, Tochigi, Japan
[2] Irish Equine Ctr, Virol Unit, Naas, Kildare, Ireland
来源：
INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2016年 / 10卷 / 06期
关键词：
challenge study; equine influenza; H3N8; inactivated whole vaccine; VACCINES; SURVEILLANCE; RACEHORSES; EFFICACY; JAPAN;
D O I：
10.1111/irv.12418
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We previously reported that horse antiserum against the Japanese equine influenza vaccine virus, A/equine/La Plata/1993 (LP93) exhibited reduced cross-neutralization against some Florida sublineage Clade (Fc) 2 viruses, for example, A/equine/Carlow/2011 (CL11). As a result, Japanese vaccine manufacturers will replace LP93 with A/equine/Yokohama/aq13/2010 (Y10, Fc2). To assess the benefit of updating the vaccine, five horses vaccinated with inactivated Y10 vaccine and five vaccinated with inactivated LP93 were challenged by exposure to a nebulized aerosol of CL11. The durations of pyrexia (>= 38.5 degrees C) and other adverse clinical symptoms experienced by the Y10 group were significantly shorter than those of the LP93 group.
引用
收藏
页码：536 / 539
页数：4
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