Underweight Is Associated with a Higher Risk of Acute Pancreatitis in Type 2 Diabetes: A Nationwide Cohort Study

被引:2
作者
Choi, Young Hoon [1 ]
Han, Kyung-Do [2 ]
Cho, In Rae [3 ,4 ]
Lee, In Seok [1 ]
Ryu, Ji Kon [3 ,4 ]
Kim, Yong-Tae [3 ,4 ]
Chung, Kwang Hyun [5 ]
Lee, Sang Hyub [3 ,4 ]
机构
[1] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul 06591, South Korea
[2] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul 06978, South Korea
[3] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul 03080, South Korea
[4] Seoul Natl Univ, Seoul Natl Univ Hosp, Liver Res Inst, Coll Med, Seoul 03080, South Korea
[5] Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Internal Med, Div Gastroenterol,Sch Med, Uijeongbu Si 11759, South Korea
关键词
pancreatitis; diabetes mellitus; type; 2; body mass index; cohort studies; nationwide studies; BODY-MASS INDEX; MELLITUS; DISEASE; METAANALYSIS; ETIOLOGY; REGISTER;
D O I
10.3390/jcm11195641
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Type 2 diabetes is known as a risk factor for acute pancreatitis, but the risk of acute pancreatitis according to glycemic status and body mass index (BMI) has remained unknown. Therefore, we aim to investigate the risk of acute pancreatitis according to BMI and glycemic status. We included 3,912,496 subjects from the Korean National Health Insurance System cohort who underwent the National Health Screening program in 2009. Each subject's clinical course was examined through follow-ups until December 2018. BMI and glycemic status were each categorized into five groups. Hazard ratios (HRs) of acute pancreatitis according to BMI and glycemic status were calculated. The adjusted HRs of acute pancreatitis were the highest in the underweight group (BMI < 18.5) in all five glycemic status categories. The HR of acute pancreatitis in the underweight group increased as the glycemic status worsened, excluding the category of diabetes for more than five years (HR 1.381 for normal fasting glucose; 1.805 for impaired fasting glucose; 2.332 for new-onset diabetes; 4.51 for diabetes duration <5 years; 4.135 for diabetes duration >= 5 years). We found that the risk of acute pancreatitis was further increased in the underweight group, depending on the status and duration of type 2 diabetes.
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页数:9
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