Glutathione and pH serial responsive functional mesoporous silica nanoparticles for drug delivery

被引：1
作者：
He, Liang [1 ,2 ]
Nan, Xueyan [1 ]
Wang, Tong [1 ]
Bai, Pengli [1 ,3 ,4 ]
机构：
[1] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China
[2] Qingdao Univ, Coll Chem & Chem Engn, Inst Biomed Mat & Engn, Qingdao 266071, Peoples R China
[3] Univ Sci & Technol China, Hefei 230026, Peoples R China
[4] Tianjin Guokeyigong Sci & Technol Dev Co Ltd, Tianjin 300399, Peoples R China
来源：
MICRO & NANO LETTERS | 2020年 / 15卷 / 05期
关键词：
CHITOSAN NANOPARTICLES; GRAPHENE OXIDE; CARBON DOTS; CO-DELIVERY; CANCER; NANOCARRIERS; DOXORUBICIN; THERAPY;
D O I：
10.1049/mnl.2019.0317
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In this work, a novel glutathione and pH serial dual-responsive drug delivery system has been developed, which was constructed with chitosan (CS), carbon dots (CDs) and hyaluronic acid (HA) modified the mesoporous silica nanoparticles (MSNs). The system showed excellent drug loading efficiency, controlled release and targeted delivery. In addition, the platform (MSN-CS@HA-CDs) exhibited fluorescence imaging property. The prepared drug delivery system appeared to be a promising cancer treatment platform.
引用
收藏
页码：291 / 295
页数：5
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