One-pot synthesis of trisubstituted 1,2-amino alcohols from deprotonated α-amino nitriles

被引：10

作者：

Kison, Coralie ^{[2
]}

Opatz, Till ^{[1
]}

机构：

[1] Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany

[2] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 16期

关键词：

amino alcohols; umpolung; amino nitriles; reduction;

D O I：

10.1002/ejoc.200701205

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short synthesis of N,1,2-trisubstituted vicinal amino alcohols by 1,2-addition of deprotonated N-monosubstituted a-amino nitrites to aldehydes and subsequent one-pot reduction of the intermediates with borane-THF is described. This procedure leads to the predominant formation of the anti-configured products. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).

引用

页码：2740 / 2745

页数：6

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