Biomedical Applications of Iron Oxide Nanoparticles: Current Insights Progress and Perspectives

被引:179
作者
Montiel Schneider, Maria Gabriela [1 ]
Martin, Maria Julia [1 ]
Otarola, Jessica [1 ]
Vakarelska, Ekaterina [2 ]
Simeonov, Vasil [2 ]
Lassalle, Veronica [1 ]
Nedyalkova, Miroslava [2 ]
机构
[1] Univ Nacl Sur UNS CONICET, Dept Quim, INQUISUR, RA-8000 Bahia Blanca, Buenos Aires, Argentina
[2] Univ Sofia, Fac Chem & Pharm, 1 James Bourchier Blvd, Sofia 1164, Bulgaria
关键词
magnetite; SPIONS; theranostics; hyperthermia; MRI; multitherapy; cancer; multimodal; MAGNETIC NANOPARTICLES; DRUG-DELIVERY; CANCER THERANOSTICS; HYBRID NANOPARTICLES; PHOTOTHERMAL THERAPY; TARGETED DELIVERY; CONTRAST AGENTS; HYPERTHERMIA; MRI; DIAGNOSIS;
D O I
10.3390/pharmaceutics14010204
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The enormous development of nanomaterials technology and the immediate response of many areas of science, research, and practice to their possible application has led to the publication of thousands of scientific papers, books, and reports. This vast amount of information requires careful classification and order, especially for specifically targeted practical needs. Therefore, the present review aims to summarize to some extent the role of iron oxide nanoparticles in biomedical research. Summarizing the fundamental properties of the magnetic iron oxide nanoparticles, the review's next focus was to classify research studies related to applying these particles for cancer diagnostics and therapy (similar to photothermal therapy, hyperthermia), in nano theranostics, multimodal therapy. Special attention is paid to research studies dealing with the opportunities of combining different nanomaterials to achieve optimal systems for biomedical application. In this regard, original data about the synthesis and characterization of nanolipidic magnetic hybrid systems are included as an example. The last section of the review is dedicated to the capacities of magnetite-based magnetic nanoparticles for the management of oncological diseases.
引用
收藏
页数:25
相关论文
共 147 条
[1]   Tomographic magnetic particle imaging of cancer targeted nanoparticles [J].
Arami, Hamed ;
Teeman, Eric ;
Troksa, Alyssa ;
Bradshaw, Haydin ;
Saatchi, Katayoun ;
Tomitaka, Asahi ;
Gambhir, Sanjiv Sam ;
Hafeli, Urs O. ;
Liggitt, Denny ;
Krishnan, Kannan M. .
NANOSCALE, 2017, 9 (47) :18723-18730
[2]   Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity [J].
Arias, Lais Salomao ;
Pessan, Juliano Pelim ;
Miranda Vieira, Ana Paula ;
Toito de Lima, Taynara Maria ;
Botazzo Delbem, Alberto Carlos ;
Monteiro, Douglas Roberto .
ANTIBIOTICS-BASEL, 2018, 7 (02)
[3]  
Arruebo Manuel, 2011, Cancers (Basel), V3, P3279, DOI 10.3390/cancers3033279
[4]   Bimodal magnetic resonance imaging-computed tomography nanoprobes: A Review [J].
Bakhtiari-Asl, Fatemeh ;
Divband, Baharak ;
Mesbahi, Asghar ;
Gharehaghaji, Nahideh .
NANOMEDICINE JOURNAL, 2020, 7 (01) :1-12
[5]   Novel and efficient MR active aqueous colloidal Fe3O4 nanoassemblies [J].
Barick, K. C. ;
Aslam, M. ;
Lin, Yen-Po ;
Bahadur, D. ;
Prasad, Pottumarthi V. ;
Dravid, Vinayak P. .
JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (38) :7023-7029
[6]   Formulation and in vitro evaluation of a siRNA delivery nanosystem decorated with gH625 peptide for triple negative breast cancer theranosis [J].
Ben Djemaa, Sanaa ;
David, Stephanie ;
Herve-Aubert, Katel ;
Falanga, Annarita ;
Galdiero, Stefania ;
Allard-Vannier, Emilie ;
Chourpa, Igor ;
Munnier, Emilie .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2018, 131 :99-108
[7]   Innovations in Instrumentation for Positron Emission Tomography [J].
Berg, Eric ;
Cherry, Simon R. .
SEMINARS IN NUCLEAR MEDICINE, 2018, 48 (04) :311-331
[8]  
Bhise K, 2017, THER DELIV, V8, P1003, DOI 10.4155/tde-2017-0062
[9]   Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date [J].
Bobo, Daniel ;
Robinson, Kye J. ;
Islam, Jiaul ;
Thurecht, Kristofer J. ;
Corrie, Simon R. .
PHARMACEUTICAL RESEARCH, 2016, 33 (10) :2373-2387
[10]   Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach [J].
Brueckl, Hubert ;
Shoshi, Astrit ;
Schrittwieser, Stefan ;
Schmid, Barbara ;
Schneeweiss, Pia ;
Mitteramskogler, Tina ;
Haslinger, Michael J. ;
Muehlberger, Michael ;
Schotter, Joerg .
SCIENTIFIC REPORTS, 2021, 11 (01)