Long-Term Exposure to Ambient Fine Particulate Matter and Incidence of Major Cardiovascular Diseases: A Prospective Study of 0.5 Million Adults in China

被引:32
作者
Liu, Cong [1 ]
Chan, Ka Hung [2 ,3 ,4 ]
Lv, Jun [5 ,6 ,7 ]
Lam, Hubert [2 ,3 ,4 ]
Newell, Katherine [2 ,3 ,4 ]
Meng, Xia [1 ]
Liu, Yang [8 ]
Chen, Renjie [1 ]
Kartsonaki, Christiana [2 ,3 ,4 ]
Wright, Neil [2 ,3 ,4 ]
Du, Huaidong [2 ,3 ,4 ]
Yang, Ling [2 ,3 ,4 ]
Chen, Yiping [2 ,3 ,4 ]
Guo, Yu [9 ]
Pei, Pei [9 ]
Yu, Canqing [5 ,6 ]
Shen, Hongbing [10 ]
Wu, Tangchun [11 ]
Kan, Haidong [1 ]
Chen, Zhengming [2 ,3 ,4 ,12 ]
Li, Liming [5 ,6 ]
机构
[1] Fudan Univ, IRDR ICoE Risk Interconnect & Governance Weather, NHC Key Lab Hlth Technol Assessment, Key Lab Publ Hlth Safety,Minist Educ,Sch Publ Hlt, Shanghai 200032, Peoples R China
[2] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Ctr Res Excellence, Oxford OX3 7LF, England
[3] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Ctr Res Excellence, Oxford OX3 7LF, England
[4] Univ Oxford, Oxford British Heart Fdn, Ctr Res Excellence, Oxford OX3 7LF, England
[5] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
[6] Peking Univ, Ctr Publ Hlth & Epidem Preparedness & Response, Beijing 100191, Peoples R China
[7] Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
[8] Emory Univ, Rollins Sch Publ Hlth, Gangarosa Dept Environm Hlth, Atlanta, GA 30322 USA
[9] Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
[10] Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Dept Epidemiol, Nanjing 211166, Peoples R China
[11] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Wuhan 430030, Peoples R China
[12] Univ Oxford, Nuffield Dept Populat Hlth, MRC Populat Hlth Res Unit, Oxford OX3 7LF, England
基金
英国惠康基金; 中国国家自然科学基金; 国家重点研发计划;
关键词
fine particulate matter; cardiovascular disease; incidence; cohort study; satellite-based modeling; ALL-CAUSE MORTALITY; AIR-POLLUTION; LUNG-CANCER; RISK; EVENTS; ASSOCIATIONS; NATIONWIDE; KADOORIE; OUTCOMES; BURDEN;
D O I
10.1021/acs.est.2c03084
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Few cohort studies explored the long-term effects of ambient fine particulate matter (PM2.5) on incidence of cardiovascular diseases (CVDs), especially in countries with higher levels of air pollution. We aimed to evaluate the association between long-term exposure to PM2.5 and incidence of CVD in China. We performed a prospective cohort study in ten regions that recruited 512,689 adults during 2004-2008, with follow-up until 2017. Annual PM2.5 concentrations were estimated using a satellite-based model with national coverage and 1 x 1 km spatial resolution. Time-varying Cox proportional hazard regression models were used to estimate hazard ratios (HRs) for all-cause and cause-specific CVDs associated with PM2.5, adjusting for conventional covariates. During 5.08 million person-years of follow-up, 148,030 incident cases of CVD were identified. Long-term exposure to PM2.5 showed positive and linear association with incidence of CVD, without a threshold below any concentration. The adjusted HRs per 10 mu g/m(3) increase in PM2.5 was 1.04 (95%CI: 1.02, 1.07) for total CVD. The risk estimates differed between certain population subgroups, with greater HRs in men, in household with higher income, and in people using unclean heating fuels. This prospective study of large Chinese population provided essential epidemiological evidence for CVD incident risk associated with PM2.5.
引用
收藏
页码:13200 / 13211
页数:12
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