A facile and efficient synthesis of fully substituted pyridin-2(1H)-ones from α-oxoketene-S,S-acetals

被引：6

作者：

Yang, Xiuyun ^{[1
]}

Cheng, Yanyan ^{[1
]}

Zhao, Fei ^{[3
]}

Li, Yunhui ^{[1
]}

Ding, Yuanli ^{[1
]}

Liang, Yongjiu ^{[2
]}

Gan, Fengjiao ^{[1
]}

Dong, Dewen ^{[2
]}

机构：

[1] Changchun Univ Sci & Technol, Sch Chem & Environm Engn, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China

[3] Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China

来源：

TETRAHEDRON | 2011年 / 67卷 / 43期

基金：

中国国家自然科学基金;

关键词：

ALPHA-CARBAMOYL KETENE-S; S-ACETALS; ONE-POT SYNTHESIS; KETENE DITHIOACETALS; VILSMEIER REACTION; MICHAEL ADDITION; ANNULATION; STRATEGY; ODORLESS; ACID; THIOACETALIZATION;

D O I：

10.1016/j.tet.2011.08.066

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient synthesis of fully substituted pyridin-2(1H)-ones has been developed by the reaction of readily available alpha-oxoketene-S,S-acetals with malononitrile in the presence of sodium methoxide in methanol under reflux. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：8343 / 8347

页数：5

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